Pentazocine-Naloxone Hcl
Pentazocine-Naloxone HCl 50-0.5MG
What is Pentazocine-Naloxone Hcl?
Pentazocine-Naloxone HCl is a combination medication used to treat moderate to severe pain. Pentazocine is an opioid analgesic that alters the perception and response to pain, while naloxone is included to prevent the misuse of the medication by blocking euphoric effects when injected. This combination is typically administered orally and is not intended for treating chronic pain.Side Effects
- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures or tremors
- Severe confusion, lightheadedness, dizziness, or fainting
- Blue lips, fingernails, or skin, fast, slow, or uneven heartbeat
Warnings
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Sleepiness or unusual drowsiness.
Prescription savings · · · ·
What is Pentazocine-Naloxone Hcl ?
Pentazocine-Naloxone HCl is a combination medication used to treat moderate to severe pain. Pentazocine is an opioid analgesic that alters the perception and response to pain, while naloxone is included to prevent the misuse of the medication by blocking euphoric effects when injected. This combination is typically administered orally and is not intended for treating chronic pain.- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures or tremors
- Severe confusion, lightheadedness, dizziness, or fainting
- Blue lips, fingernails, or skin, fast, slow, or uneven heartbeat
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Severe constipation, stomach pain
- Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash
- Seizures or tremors.
- Sleepiness or unusual drowsiness.
- Severe confusion or hallucinations (seeing things that are not there).
- Severe stomach pain.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Sleepiness or unusual drowsiness.
- Severe stomach pain.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, low blood pressure, a recent heart attack, adrenal problems, lung or breathing problems (including COPD, apnea), gallbladder problems, spine problems, mental illness, pancreas problems, porphyria, thyroid problems, prostate problems, trouble urinating, or a history of head injury, seizures, or alcohol or drug abuse. Tell your doctor if you have had any type of surgery.
- This medicine may cause the following problems:Increased risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Increased risk of seizuresSerotonin syndrome, when used with certain medicines
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Pentazocine-Naloxone Hcl Coupons & Prices
Pentazocine-Naloxone HCl 50-0.5MG
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Looking for a pentazocine and naloxone HCl coupon? Pentazocine/naloxone is the generic, oral form of the brand Talwin Nx, a prescription opioid pain medicine used to relieve moderate to severe pain. Because it is a generic, it is generally low-cost, but the cash price can vary widely from one pharmacy to the next, which is why comparing matters. Rx.com checks prices across more than 60,000 pharmacies so you can find the lowest cash price near you. Enter your ZIP above to see today's price on pentazocine and naloxone HCl.
What is pentazocine and naloxone HCl, and how does it work?
Pentazocine and naloxone hydrochloride is a combination tablet taken by mouth. Pentazocine is a mixed agonist-antagonist opioid (narcotic) analgesic that relieves pain by acting on the central nervous system. It is FDA-approved for the relief of moderate to severe pain and is a Schedule C-IV controlled substance. The tablet was originally sold under the brand name Talwin Nx, which is largely discontinued; today it is supplied as generic pentazocine/naloxone HCl tablets.
The small 0.5 mg dose of naloxone in each tablet has no meaningful effect when the tablet is swallowed as directed. It is included only as an abuse deterrent: if someone were to dissolve and inject the tablet, the naloxone would block pentazocine's opioid effect. This medicine is intended for oral use only and is not for children under 12. Always take it exactly as your provider prescribes.
Cost of pentazocine and naloxone HCl without insurance
As a generic, pentazocine and naloxone HCl is usually one of the more affordable pain medicines, but there is no single set price. What you pay in cash can differ significantly depending on the pharmacy you choose, even within the same town, so it pays to compare before you fill. The brand Talwin Nx is largely discontinued, and there is no manufacturer savings card for this product, so a discount coupon is the practical way to lower the cash price.
Rx.com compares cash prices across more than 60,000 pharmacies and gives you a free coupon you can show at the counter. There is no membership or insurance required. Enter your ZIP above to see today's price on pentazocine and naloxone HCl at pharmacies near you.
Related pain medicines and alternatives
If you are comparing options with your provider, several other pain medicines and combination products are commonly discussed. These work in different ways and carry their own risks, so only your prescriber can decide what is right for you. You can compare cash prices on Rx.com for related medicines such as:
- tramadol
- hydrocodone/acetaminophen
- acetaminophen with codeine
- buprenorphine/naloxone
- naloxone
Do not switch medicines on your own. This list is for price comparison only and is not a recommendation to substitute one drug for another.
Important safety information
Like all opioids, pentazocine and naloxone carries boxed warnings. There is a risk of addiction, abuse, and misuse that can lead to overdose and death, and a risk of life-threatening respiratory depression. Combining it with benzodiazepines, alcohol, or other central nervous system depressants can cause dangerous or fatal sedation and slowed breathing. Prolonged use during pregnancy can cause neonatal opioid withdrawal syndrome. Because pentazocine is a mixed agonist-antagonist, it can also trigger withdrawal in people who are dependent on pure opioid agonists.
Other possible effects include dizziness, sedation, confusion, hallucinations, and, rarely, seizures. Extra caution is needed with head injury, breathing problems, or liver or kidney impairment, and injecting the tablet is dangerous. This information is not medical advice. Talk with your doctor or pharmacist about your full health history and all the medicines you take before starting or stopping this medication.
This Pentazocine-Naloxone Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Pentazocine-Naloxone Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.