Hormone therapy

Progesterone, prescribed online

Prescription micronized progesterone, the hormone most women with a uterus need alongside estrogen in menopause hormone therapy. A U.S.-licensed provider reviews your health history and decides whether it is right for you.

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Micronized ProgesteroneCapsule taken at bedtime

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Why progesterone goes with estrogen

Estrogen is the hormone that relieves hot flashes and night sweats. But if you still have a uterus, estrogen on its own can overgrow the uterine lining (endometrial hyperplasia) and raise the risk of endometrial cancer. Adding a progestogen protects the lining.

Micronized progesterone is chemically the same as the progesterone your ovaries make. It is taken by mouth at bedtime, either every day or on part of each month, on the schedule your provider sets.

Looking for estrogen too? See estrogen therapy from Rx.com.

It may be prescribed for women who:

Have a uterus and take estrogen pills, patches or gel
Are in perimenopause or menopause hormone therapy
Have missed periods (amenorrhea) when a provider decides it fits

Get started in 3 steps

100% online, with free shipping if a prescription is approved.

Answer a health questionnaire

A short, confidential online intake about your symptoms, hormone therapy and health history.

A provider reviews it

A U.S.-licensed provider decides whether progesterone is right for you, and the dose and schedule.

Get your medication

A licensed U.S. pharmacy fills your prescription and ships it to your door.

Progesterone FAQs

What is progesterone used for in hormone therapy?

If you still have a uterus and take systemic estrogen (a pill, patch or gel) for menopause symptoms, estrogen alone can thicken the uterine lining and raise the risk of endometrial cancer. Taking progesterone alongside it protects the lining. Your provider decides whether you need it and on what schedule.

What is micronized progesterone?

It is progesterone that is chemically the same as the hormone the ovaries make, ground into very fine particles so it absorbs well when taken by mouth. In the U.S. it is sold as the brand Prometrium and as generic progesterone capsules.

Is progesterone the same as estrogen?

No. They are two different hormones. Estrogen relieves hot flashes, night sweats and vaginal dryness. Progesterone is mainly added to protect the uterus when you take estrogen. Many women in hormone therapy take both, but one does not replace the other.

Do I need progesterone if I had a hysterectomy?

Usually not. Women without a uterus generally take estrogen alone. Your provider will confirm this based on your history.

Why is it taken at bedtime?

Oral progesterone can cause drowsiness or dizziness, so the label says to take it at bedtime. Some women find it helps them sleep. Do not drive or operate machinery until you know how it affects you.

What side effects can progesterone cause?

Common ones include drowsiness, dizziness, breast tenderness, headache, bloating, mood changes and spotting, especially in the first few months. Tell your provider about any side effect that bothers you or does not go away.

Can I take it if I am allergic to peanuts?

Tell your provider. Prometrium and many generic progesterone capsules contain peanut oil, so they are not for people with a peanut allergy.

Do I need a prescription?

Yes. Progesterone is prescription only. You complete an online health questionnaire, a U.S.-licensed provider reviews it, and if treatment is appropriate a U.S.-licensed pharmacy fills your prescription and ships it to you.

I already have a progesterone prescription. What is cheapest?

Generic progesterone is often inexpensive at a local pharmacy. If you already have a prescription, check your insurance copay and compare free Rx.com coupon prices below before you pay.

Important safety information

Estrogens plus progestins should not be used to prevent heart disease or dementia. In a large study of postmenopausal women (the Women's Health Initiative), estrogen plus a progestin was linked to higher risks of heart attack, stroke, invasive breast cancer, blood clots in the lungs and legs, and probable dementia in women 65 and older. Use the lowest effective dose for the shortest time that meets your treatment goals.

Do not use progesterone if you have unusual vaginal bleeding that has not been evaluated, have or have had breast cancer, have had a blood clot, stroke or heart attack, have liver disease, are allergic to progesterone or peanuts, or are pregnant. Get emergency care for chest pain, shortness of breath, pain or swelling in one leg, sudden severe headache or vision changes.

Prescription required. Medications are only prescribed when clinically appropriate after an evaluation by a licensed independent provider. Rx.com provides the technology platform and does not practice medicine.

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Progesterone

Progesterone 100MG

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What is Progesterone?

Progesterone is a prescription hormone medication used to support fertility, pregnancy, hormone replacement therapy (HRT), and menstrual health. It helps regulate the menstrual cycle, prepare the uterus for pregnancy, and balance estrogen levels in women with low progesterone.

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What is Progesterone ?

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Breast lumps
Chest pain, trouble breathing, or coughing up blood
Depression
Heavy or nonstop vaginal bleeding
Rapid weight gain, swelling in your hands, ankles, or feet
Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

This medicine may cause the following problems:Blood clots, which could lead to stroke, heart attack, or other serious problemsDementia (when used together with estrogen in women older than 65)Increased risk of breast or endometrial cancer (when used together with estrogen)
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. You may also need to stop if you will be inactive for a long time. This medicine may affect certain medical test results.
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Rapid weight gain, swelling in your hands, ankles, or feet
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, lupus, thyroid problems, or a history of depression. Tell your doctor about any problems with your heart or blood, such as heart disease, blood clotting problems, high blood pressure, or high cholesterol. Tell your doctor if you smoke.

What is progesterone used for? ▼

Oral micronized progesterone (Prometrium) is FDA-approved to prevent overgrowth of the uterine lining in postmenopausal women who take estrogen and still have a uterus, and to treat secondary amenorrhea by helping bring on menstruation when periods have stopped from a lack of progesterone. Vaginal forms such as Crinone and Endometrin are used for progesterone supplementation in IVF and for secondary amenorrhea. Some providers also prescribe it off-label; your provider can explain what is right for you.

Is progesterone the same as Prometrium? ▼

Prometrium is the brand name for oral micronized progesterone, and generic progesterone contains the same active ingredient. The main difference is usually the price. Because progesterone comes in several forms (oral capsules and vaginal gels or inserts), check with your pharmacist that you are getting the exact formulation your provider prescribed.

What are the side effects of taking progesterone? ▼

Common effects can include drowsiness and dizziness, which is why it is often taken at bedtime. More serious risks can include blood clots, stroke, and breast changes. Seek medical help right away for leg swelling or pain, sudden shortness of breath, chest pain, severe headache, vision changes, facial drooping, or a new breast lump. Prometrium capsules also contain peanut oil and should be avoided by anyone with a peanut allergy. Talk to your provider about your personal risks.

Should progesterone be taken at night? ▼

Oral progesterone can cause drowsiness or dizziness, so many providers recommend taking it at bedtime. Always follow the specific directions your provider or pharmacist gives you for your prescription.

Does progesterone cause weight gain? ▼

Progesterone affects people differently. Discuss any concerns about weight or other side effects with your provider or pharmacist, who can review how the medication is working for you. This is general information and not a substitute for medical advice.

How much does Progesterone 100MG cost without insurance? ▼

The price of Progesterone 100MG without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.

What are the common side effects of Progesterone 100MG? ▼

Common side effects of Progesterone 100MG may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Breast lumps, Chest pain, trouble breathing, or coughing up blood, Depression, Heavy or nonstop vaginal bleeding. This is not a complete list — consult your pharmacist or doctor for full side effect information.

Is there a generic version of Progesterone 100MG? ▼

Generic versions may be available for Progesterone 100MG. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Progesterone 100MG on Rx.com to compare generic and brand prices at pharmacies near you.

What is the cheapest pharmacy for Progesterone 100MG? ▼

The cheapest pharmacy for Progesterone 100MG depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Progesterone 100MG near you.

Progesterone Coupons & Prices

Progesterone 100MG

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Progesterone prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage	Quantity	Retail price	Rx.com price
100mg · Capsule	30	$31.39	$14.75
200mg · Capsule	30	$48.89	$19.39

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a progesterone coupon? Progesterone (micronized) is a female sex hormone available as a low-cost generic, so you often do not need insurance to pay a fair cash price. Cash prices still vary widely from one pharmacy to the next, which is exactly why comparing matters. Rx.com checks progesterone prices across more than 60,000 U.S. pharmacies so you can enter your ZIP above to see today's price and grab a free discount coupon to use at the register.

What is progesterone and how does it work?

Progesterone is a progestin (a progestogen, or female sex hormone). Oral micronized progesterone, sold under the brand name Prometrium, is FDA-approved to prevent endometrial hyperplasia (overgrowth of the uterine lining) in postmenopausal women who still have a uterus and are taking estrogen as part of menopausal hormone therapy. It is also approved to treat secondary amenorrhea, meaning it can help bring on menstruation in women whose periods have stopped due to a lack of progesterone.

Vaginal formulations such as Crinone and Endometrin are used for progesterone supplementation and replacement in assisted reproductive technology (IVF) and for secondary amenorrhea. Progesterone is also prescribed off-label by some providers for luteal phase support during fertility treatment and other uses; your provider can explain whether progesterone is right for your situation.

Progesterone cost without insurance and how to save

Progesterone is available as a generic, so it is generally one of the more affordable hormone medications. Even so, the cash price you pay can differ a lot depending on which pharmacy you use, your dose, and your formulation (oral capsule versus vaginal gel or insert). Because the same prescription can cost noticeably more at one pharmacy than another nearby, it pays to compare before you fill.

Rx.com compares progesterone prices across more than 60,000 pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price at pharmacies near you. There is no manufacturer savings card for generic progesterone, but the generic itself is typically inexpensive, and comparing prices is the most reliable way to keep your cost down.

Progesterone vs. related hormone options

Progesterone belongs to a group of hormone medications, and your provider chooses among them based on your needs. Micronized progesterone is the same active ingredient as brand-name Prometrium. It is often prescribed alongside estradiol for menopausal hormone therapy, and it is also available combined with estradiol in the brand Bijuva.

Other progestins your provider might consider include medroxyprogesterone and norethindrone. These are different medications with their own dosing and considerations, so only your provider can decide which is appropriate for you. Whichever one you are prescribed, you can compare its cash price and find a coupon on Rx.com.

Progesterone safety and side effects

Progesterone can cause drowsiness or dizziness, which is one reason many providers suggest taking the oral capsule at bedtime. Avoid grapefruit juice while taking it, and note that it can interact with CYP3A4 inducers such as St. John's wort. Prometrium capsules contain peanut oil, so they should not be used by anyone allergic to peanuts. Progesterone is not appropriate for everyone; it is contraindicated in known or suspected pregnancy loss, undiagnosed vaginal bleeding, active or past blood-clotting disorders, liver dysfunction, and known or suspected breast cancer.

Serious risks can include blood clots, stroke, and breast changes. Get medical help right away if you have leg swelling or pain, sudden shortness of breath, chest pain, a severe headache, vision changes, facial drooping, or a new breast lump. Historically, progesterone used in menopausal hormone therapy carried a boxed warning about cardiovascular events, stroke, blood clots, invasive breast cancer, and probable dementia based on the Women's Health Initiative; in November 2025 the FDA directed removal of that boxed warning from Prometrium and several other menopausal hormone therapy products after a literature review. This is general information, not medical advice; talk with your provider or pharmacist about the risks and benefits for you.

Sources & accuracy

This Progesterone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Progesterone on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

Progesterone — Articles & Guides

27 articles

Can You Start HRT While You Still Have Periods?

Doctors once advised waiting 12 months after the last period to start hormone replacement therapy. New guidance says many women can begin low-dose estrogen during perimenopause to ease hot flashes, sleep problems, and mood changes, if contraception and bleeding patterns are managed. This guide explains how to decide, what to expect, and where to get prescription estrogen online.

Online Menopause Care vs an In-Person OB-GYN

Thinking about managing hot flashes and night sweats online? This guide explains what telehealth can (and can’t) do for menopause, how to get an estradiol prescription from Rx.com, and the red-flag symptoms that still require an in-person pelvic exam.

Do You Need Progesterone With Estrogen? The Uterus Rule Explained

Wondering if you need progesterone with your estrogen prescription? This guide breaks down the “uterus rule,” the science of endometrial protection, when a levonorgestrel IUD is enough, and why low-dose vaginal estrogen is different.

Progesterone Side Effects: Common, Serious and When to Call a Doctor

Oral micronized progesterone (Prometrium® and generics) can cause dizziness, breast tenderness, and, when combined with estrogen, rare but serious events such as blood clots or breast cancer. Learn what is normal, when to call your doctor, and how to get prescribed progesterone safely online.

Progesterone 100 mg Capsules: What They Treat and How to Take Them

A 100 mg micronized progesterone capsule is the dose most menopause specialists use to protect the uterine lining when you take estrogen therapy every day. This guide explains how it works, how to swallow it safely at bedtime, peanut-oil warnings, side effects to watch for, and the fastest way to get an online prescription from a licensed provider on Rx.com.

Menopause Treatment Online With No Membership Fees

Hot flashes waking you up? Discover how Rx.com delivers FDA-approved estradiol for menopause relief with zero membership fees, free shipping, and transparent pharmacy price comparisons, all from an online visit.

Do You Need Blood Tests Before Starting Estrogen?

Reddit forums buzz with the question: Do you really need blood work before your doctor can prescribe estrogen for hot flashes or night sweats? This guide explains when menopause is diagnosed clinically, which tests help in special cases, how to monitor safety, and how to start treatment online with Rx.com.

Progesterone for Menopause: Benefits, Dosage and How to Start

Thinking about adding progesterone to your menopause treatment? This guide explains why progesterone is paired with estrogen, the most common 100-mg and 200-mg regimens, benefits, side-effects, and how to get a prescription shipped to your door through Rx.com.

Progesterone Supplements: Do Over-the-Counter Products Work?

Over-the-counter “progesterone” creams and wild-yam pills are not FDA-approved and rarely raise hormone levels. This guide explains the evidence, safety concerns, and when a prescription capsule is the right move, with tips on getting progesterone online through Rx.com.

Estrogen vs Progesterone: What Is the Difference?

Estrogen and progesterone work together to regulate the menstrual cycle and protect the uterus during hormone therapy. This in-depth guide compares their roles, benefits, risks, and the forms your provider may prescribe, plus how to get progesterone online through Rx.com.

Am I in Perimenopause? 15 Signs Women Miss in Their 40s

Wondering if you are “too young” for menopause symptoms? This guide explains 15 easy-to-miss signs of perimenopause, how long the transition usually lasts, why labs are often normal, and the treatment options, including estradiol therapy, that really work.

Is It Too Late to Start HRT After 60?

Many women first consider hormone replacement therapy (HRT) well into their 60s. This guide explains the 10-year timing rule, who can still benefit, safer delivery methods like patches and vaginal cream, and how to discuss late-start HRT with your doctor.

Online HRT for Perimenopause: How It Works

Perimenopause can bring hot flashes, mood swings, and sleep trouble years before your last period. This guide shows how online hormone replacement therapy (HRT) with estradiol works, what to expect from a virtual visit, and how Rx.com delivers affordable estrogen treatment to your door.

Is 200 mg of Progesterone a High Dose? Progesterone 200 mg Explained

A 200 mg progesterone capsule is the higher of the two standard oral strengths. This guide explains why doctors prescribe 200 mg during cyclic hormone therapy, how it compares with 100 mg daily, potential side effects, and how to get progesterone online through Rx.com.

Low Progesterone Symptoms in Women: Signs, Causes and Treatment

Wondering if your fatigue, spotting, or poor sleep could be due to low progesterone? This guide explains what science says about low progesterone symptoms, how and when to test, and evidence-based treatment options including online progesterone prescriptions.

Does Progesterone Make You Tired? Progesterone and Sleep

Oral progesterone often causes calm or drowsy feelings because its metabolites bind to the same brain receptors as sleep medicines. This guide explains how common fatigue really is, why the FDA label tells you to take it at bedtime, and practical ways to stay safe while still getting the benefits of progesterone therapy.

Bioidentical Progesterone: What It Is and How to Get It Prescribed

Bioidentical progesterone is the FDA-approved micronized form of the body’s own hormone. Learn how it works, how it compares with compounded pellets and creams, the real risks, and how to get a prescription from a licensed U.S. provider through Rx.com.

Get Estradiol Gel Online

Estradiol gel is a smooth, patch-free way to deliver estrogen through the skin. Learn who benefits most, how it compares to patches, and the easiest way to get it prescribed through a licensed online provider on Rx.com.

How to Get a Progesterone Prescription Online

Thinking about starting progesterone but do not want an extra trip to the doctor’s office? This guide explains exactly how an online visit for micronized progesterone works, who is a good candidate, what questions the provider will ask, and when in-person gynecology care is still the safer choice.

Prometrium Cost Without Insurance: Brand vs Generic Progesterone Prices

Brand-name Prometrium can be several times more expensive than its FDA-approved generic. This guide explains the real cash prices, insurance and Medicare coverage rules, and how to get a prescription filled for less through Rx.com.

Does Insurance Cover Progesterone? Medicare, Medicaid and Cash Options

Generic progesterone is usually covered by employer plans, Medicare drug plans and Medicaid, but your cost depends on tier and deductible. Here is how coverage works and when a coupon or cash price is cheaper.

Switching Your HRT Prescription to an Online Provider

Already on hormone replacement therapy and want the convenience of online refills? This guide shows exactly how to transfer your current HRT prescription, what medical records to gather, how to keep the same dose and formulation, and where to compare prices so you never miss a refill.

How to Get Estrogen Prescribed Online

Ready to start estrogen therapy without leaving home? Learn how online doctors evaluate your symptoms, choose the right estradiol dose and dosage form, and ship medication straight to your door. We also cover who qualifies, red-flag risks, and how to cut cash prices with a free Rx.com discount card.

Spotting or Bleeding After Starting HRT: What's Normal

Noticing light bleeding after starting hormone replacement therapy? Most women see spotting taper off within the first three to six months, but certain patterns signal it is time for a pelvic exam. This guide explains why early bleeding happens, how different HRT regimens compare, and the warning signs that need medical evaluation.

Hot Flash Treatment Online: Prescription Options

Menopausal hot flashes can disrupt sleep, work, and your quality of life. Learn why estrogen therapy is the gold-standard treatment, which non-hormonal medications help when estrogen is not an option, and how to get a same-day prescription online through Rx.com.

Menopause Brain Fog: Can Estrogen Help?

Feel like you keep losing words since perimenopause started? Learn what causes menopause brain fog, who is most affected, and the evidence (and limits) behind estrogen therapy for sharper thinking.

Can Estrogen Help Menopause Insomnia and Night Sweats?

Waking drenched at 3 a.m.? Hot flashes and night sweats shatter sleep for millions of mid-life women. Learn why falling estrogen disrupts your body-clock, how prescription estradiol calms vasomotor symptoms, and which bedtime tweaks actually work.

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.

Progesterone, prescribed online

Why progesterone goes with estrogen

It may be prescribed for women who:

Get started in 3 steps

Answer a health questionnaire

A provider reviews it

Get your medication

Progesterone FAQs

Important safety information

What is Progesterone?

Side Effects

Warnings

What is Progesterone ?

Progesterone Coupons & Prices

Progesterone Coupons & Prices

Progesterone prices by dosage

What is progesterone and how does it work?

Progesterone cost without insurance and how to save

Progesterone vs. related hormone options

Progesterone safety and side effects

Progesterone — Articles & Guides

Related Drugs

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