Rifabutin
Rifabutin 150MG
What is Rifabutin?
Mycobutin is used to prevent mycobacterium avium complex (MAC) in people with HIV infection. It is also used to treat tuberculosis in people with HIV. The generic version of Mycobutin is rifabutin. The cost for 100, 150 mg Mycobutin oral capsule is around $3,322. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.Side Effects
- Blurred vision or loss of vision, eye redness, pain, or sensitivity to light
- Unusual bleeding, bruising, or weakness
- Blistering, peeling, red skin rash
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, muscle problems, or eye or vision problems.
- This medicine may cause the following problems:Eye or vision problemsSerious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine should not be given to patients with active tuberculosis (TB). If you think you may have active TB, tell your doctor.
- This medicine may cause your skin, tears, saliva, sweat, urine, or bowel movements to turn a brownish-orange color. Your contact lenses could become permanently discolored.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
Prescription savings · · · ·
What is Rifabutin ?
Mycobutin is used to prevent mycobacterium avium complex (MAC) in people with HIV infection. It is also used to treat tuberculosis in people with HIV. The generic version of Mycobutin is rifabutin. The cost for 100, 150 mg Mycobutin oral capsule is around $3,322. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.- Blurred vision or loss of vision, eye redness, pain, or sensitivity to light
- Unusual bleeding, bruising, or weakness
- Blistering, peeling, red skin rash
- Fever, chills, cough, sore throat, and body aches
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Lightheadedness or fainting
- Diarrhea that may contain blood
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, muscle problems, or eye or vision problems.
- This medicine may cause the following problems:Eye or vision problemsSerious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine should not be given to patients with active tuberculosis (TB). If you think you may have active TB, tell your doctor.
- This medicine may cause your skin, tears, saliva, sweat, urine, or bowel movements to turn a brownish-orange color. Your contact lenses could become permanently discolored.
- This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
Rifabutin Coupons & Prices
Rifabutin 150MG
4 ED medications in one dose
Sildenafil, tadalafil, vardenafil & apomorphine · Works in ~15 min · Lasts up to 36 hours
Rifabutin prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 150mg · Capsule | 60 | $1,053.99 | $216.18 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a rifabutin coupon? Rifabutin is the low-cost generic version of Mycobutin, a rifamycin-family antibiotic used to prevent disseminated Mycobacterium avium complex (MAC) disease in people with advanced HIV. Because it is a generic, the cash price is often already modest, but what you pay can vary widely from one pharmacy to the next. Rx.com compares live prices across more than 60,000 U.S. pharmacies, so you can enter your ZIP code above to see today's price near you and use a free rifabutin discount coupon at checkout.
What is rifabutin and how does it work?
Rifabutin is an antimycobacterial antibiotic derived from the rifamycin class. It is FDA-approved to prevent disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection. It works by interfering with the bacteria's ability to grow and multiply.
Beyond that approved use, doctors sometimes include rifabutin in combination regimens for active tuberculosis, particularly in people who are HIV-positive, because it causes fewer interactions with certain HIV medicines than rifampin. It is also used in some combination treatments for MAC and other nontuberculous mycobacterial infections and, in select regimens, to help eradicate H. pylori. Rifabutin should never be taken alone to treat active tuberculosis, since single-drug therapy can lead to drug resistance. This information is educational and is not a substitute for advice from your own healthcare provider.
Rifabutin cost without insurance and how to save
Rifabutin is available as a generic, which usually keeps its cash price lower than brand-name Mycobutin. Even so, generic prices are not the same everywhere. The amount you pay without insurance can differ significantly from pharmacy to pharmacy in the very same town, which is exactly why comparing before you fill matters.
Rx.com checks live prices at more than 60,000 pharmacies and shows you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you. There is no manufacturer savings card for generic rifabutin, so a cash discount coupon is typically the most practical way to lower your out-of-pocket cost.
Rifabutin vs. Mycobutin and related antibiotics
Rifabutin and Mycobutin are the same medicine; Mycobutin is simply the brand name and rifabutin is the generic. In most cases the generic delivers the same active ingredient at a lower cost.
Rifabutin belongs to the same rifamycin family as rifampin and rifapentine, though it is not interchangeable with them and is chosen in specific situations. Depending on the infection and the treatment plan, providers may combine rifabutin with other antimycobacterial or antibiotic drugs such as clarithromycin, azithromycin, ethambutol, or isoniazid. Which combination is right depends on your diagnosis and should always be decided by your care team. If you have been prescribed any of these, you can compare prices for each on Rx.com to keep the whole regimen affordable.
Rifabutin safety and side effects
Rifabutin has no boxed warning, but there are important cautions. It should not be used by anyone who is allergic to rifabutin or other rifamycins, and it must not be combined with delavirdine or voriconazole. It is a strong inducer of the CYP3A4 enzyme, so it interacts with many other medicines, and dosing of both rifabutin and certain HIV medicines often needs to be adjusted. It can also make hormonal birth control less effective, so ask your provider about backup contraception.
Rifabutin can lower white blood cell and platelet counts, so your doctor may check your blood counts periodically. It may cause eye inflammation known as uveitis (more likely at higher doses or when taken with clarithromycin or fluconazole), and rarely more serious skin, gastrointestinal, or C. difficile-related reactions. Harmlessly, it can turn urine, tears, sweat, and other body fluids a red-orange color and can permanently stain soft contact lenses. Tell your provider about all the medicines you take and report any new symptoms. This is general information, not medical advice, so follow your prescriber's guidance.
This Rifabutin information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Rifabutin on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Browse more medications: starting with R · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.