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Spravato (84 Mg Dose) Solution Therapy Pack — prescription drug image

Spravato (84 Mg Dose)

Spravato (84 MG Dose) 28MG/DEVICE

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What is Spravato (84 Mg Dose)?

Spravato is a nasal spray used to treat depression in adults. It may help improve mood and reduce feelings of sadness or hopelessness.

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What is Spravato (84 Mg Dose) ?

Spravato is a nasal spray used to treat depression in adults. It may help improve mood and reduce feelings of sadness or hopelessness.

Source: MedlinePlus, U.S. National Library of Medicine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloody or cloudy urine, difficult or painful urination, frequent urge to urinate
  • Blue lips, fingernails, or skin, trouble breathing, chest pain
  • Confusion about identity, place, and time
  • Lightheadedness, dizziness, or fainting
  • Prolonged drowsiness or sleepiness
  • Sudden, severe headache, vision changes, seizures, loss of consciousness, memory loss
  • Thoughts or attempts of killing yourself or others, changes in behavior
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine.
  • Do not breastfeed during treatment with this medicine.
  • Tell you doctor if you have liver disease, high blood pressure, heart or blood vessel problems, heart failure, mental illness, or if you have a history of brain problems, heart attack, stroke, or drug abuse.
  • This medicine may cause the following problems:Prolonged drowsiness or mental changes, including confusion about identity, place, and time, feeling of unreality, sense of detachment from self or bodyLung or breathing problems, including respiratory depressionChanges in mood or behavior, including thoughts or behavior of suicideHigh blood pressureBladder problems, including ulcer
  • This medicine may make you drowsy, confused, or have problems with thinking clearly. Do not drive or do anything else that could be dangerous until the next day after a restful sleep or until you know how this medicine affects you. You may also need someone to drive you home after treatment with this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
How much does Spravato (esketamine) cost without insurance?
The cash price for Spravato (esketamine) can vary, and because it must be given in a certified healthcare setting, costs may include the medication and the supervised session. We do not list a fixed dollar amount here because prices change and are shown live on this page. Enter your ZIP code above to see today's Rx.com price for esketamine near you, and compare it with your insurance and the manufacturer savings program.
Is there a generic version of Spravato available?
No. There is currently no generic version of Spravato (esketamine). Because there is no generic substitute, the main ways to lower your cost are checking the manufacturer savings program (generally for people with commercial insurance) and comparing an Rx.com cash coupon price, which you can use if you are uninsured, have Medicare, or if the manufacturer card is declined.
Why do you have to be monitored for 2 hours after a Spravato dose?
Spravato can cause sedation and dissociation (feeling disconnected from yourself or your surroundings) and can raise blood pressure. Because of these effects, you must take it under direct healthcare provider observation and be monitored for at least 2 hours after each dose so your provider can watch for these reactions before you leave. You also should not drive until the next day after a restful night's sleep.
What is the difference between the 56 mg and 84 mg Spravato dose?
Both 56 mg and 84 mg are standard maintenance or target doses of Spravato. Esketamine nasal spray comes in 28 mg devices, so a 56 mg dose is given as two devices and an 84 mg dose is given as three devices during one supervised session. Your provider chooses the dose based on how you respond to treatment and your individual needs.
Is Spravato a controlled substance?
Yes. Spravato (esketamine) is a Schedule III (C-III) controlled substance because of its potential for abuse and misuse. This is one reason it is only available through the restricted SPRAVATO REMS program and must be given under the direct observation of a healthcare provider in a certified setting.
How much does Spravato (84 Mg Dose) cost without insurance?
The price of Spravato (84 Mg Dose) without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 30% off retail prices with a free Rx.com coupon.
What are the common side effects of Spravato (84 Mg Dose)?
Common side effects of Spravato (84 Mg Dose) may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Bloody or cloudy urine, difficult or painful urination, frequent urge to urinate, Blue lips, fingernails, or skin, trouble breathing, chest pain, Confusion about identity, place, and time, Lightheadedness, dizziness, or fainting. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Spravato (84 Mg Dose)?
Generic versions may be available for Spravato (84 Mg Dose). Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Spravato (84 Mg Dose) on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Spravato (84 Mg Dose)?
The cheapest pharmacy for Spravato (84 Mg Dose) depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Spravato (84 Mg Dose) near you.

Spravato (84 Mg Dose) Coupons & Prices

Spravato (84 MG Dose) 28MG/DEVICE

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Spravato (84 Mg Dose) Solution Therapy Pack — prescription drug image
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Looking for a Spravato 84 mg dose coupon? Spravato (esketamine) is a brand-name nasal spray used for treatment-resistant depression, and there is currently no generic version. Because it is only available through certified healthcare settings, the price you pay can vary widely. Enter your ZIP code above to see today's Rx.com price for esketamine near you, and read on to compare the manufacturer savings card with an Rx.com cash coupon so you can find the lowest cost for your situation.

What is the Spravato 84 mg dose and how does it work?

Spravato is the brand name for esketamine, an NMDA receptor antagonist that works differently from standard oral antidepressants. It is FDA-approved for treatment-resistant depression (TRD) in adults, used either on its own or together with an oral antidepressant, and for depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behavior (given with an oral antidepressant).

Spravato comes as a nasal spray in 28 mg devices. The 84 mg dose is one of the standard maintenance or target doses (the other being 56 mg), and it is given as three 28 mg devices during a single supervised session. This is not medical advice; your provider decides the right dose and schedule for you.

Spravato cost and savings: manufacturer card vs. Rx.com cash coupon

The manufacturer offers a Spravato savings program at spravato.com/savings-and-resources. Manufacturer savings cards are generally limited to people with commercial (private) insurance and typically exclude those with Medicare, Medicaid, or no insurance. Terms, eligibility, and any dollar limits are set by the manufacturer and can change, so check the official page for current details.

An Rx.com cash coupon works differently: it is a cash-price discount you can use even if you are uninsured, have Medicare, or if the manufacturer card is declined for you. You do not use insurance and the coupon together. To compare your options, enter your ZIP code above to see today's Rx.com price for esketamine, then weigh that against your insurance and the manufacturer program. Because Spravato has no generic, there is unfortunately no lower-cost generic version to switch to at this time.

Related medications and dosing options

If you are researching esketamine, you may also want to look at these related pages to compare doses and options with your provider:

  • Spravato — the main brand page for esketamine nasal spray.
  • Esketamine — the active ingredient in Spravato.
  • Spravato 56 mg dose — the other standard maintenance/target dose, given as two 28 mg devices.
  • Ketamine — a related medication your provider may discuss.

Which dose is right depends on how you respond to treatment and your provider's judgment. This information is for comparison only and is not a recommendation.

Important safety information

Spravato is available only through the restricted SPRAVATO REMS program. You cannot pick it up at a retail pharmacy and take it at home. It must be self-administered under the direct observation of a healthcare provider in a certified setting, and you are monitored for at least 2 hours after each dose. Spravato is a Schedule III controlled substance and carries boxed warnings for sedation, dissociation, abuse and misuse, and an increased risk of suicidal thoughts and behaviors in patients up to age 24. You should not drive until the next day after a restful night's sleep.

Other risks include increased blood pressure, breathing problems (especially with other central nervous system depressants), and effects on memory and thinking. Spravato should not be used by people with certain blood-vessel conditions (such as aneurysmal vascular disease, arteriovenous malformation, or a history of bleeding in the brain), by those allergic to esketamine or ketamine, and it is not recommended during pregnancy. This is a summary, not a complete list. Always talk with your healthcare provider about whether Spravato is right for you.

Sources & accuracy

This Spravato (84 Mg Dose) information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Spravato (84 Mg Dose) on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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