Sulfasalazine
sulfaSALAzine 500MG
What is Sulfasalazine?
Sulfasalazine is a medication used to treat ulcerative colitis, a condition that causes swelling and sores in the colon and rectum. It is also prescribed for rheumatoid arthritis and certain types of childhood arthritis, helping to reduce inflammation in the body.Side Effects
- Unusual bleeding, bruising, or weakness
- Swollen, painful, or tender lymph glands in your neck, armpit, or groin
- Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, trouble urinating, asthma, blood or bone marrow problems, or an enzyme problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- This medicine may decrease the amount of sperm a man makes and affect his ability to have children while using this medicine. If you are a man who plans to have children, talk with your doctor first.
- This medicine may cause the following problems.Liver problemsAnemia or other blood problemsSerious infectionsHeart problems, including myocarditis, pericarditisSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP)
- Your skin or urine may turn orange or yellow while you are using this medicine. This is normal and nothing to worry about.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Prescription savings · · · ·
What is Sulfasalazine ?
Sulfasalazine is a medication used to treat ulcerative colitis, a condition that causes swelling and sores in the colon and rectum. It is also prescribed for rheumatoid arthritis and certain types of childhood arthritis, helping to reduce inflammation in the body.- Unusual bleeding, bruising, or weakness
- Swollen, painful, or tender lymph glands in your neck, armpit, or groin
- Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
- Bloody diarrhea, severe cramping, stomach pain, headache
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Chest pain, trouble breathing
- Fever, chills, cough, sore throat, pale skin, body aches
- Change in how much or how often you urinate, difficult or painful urination, lower back or side pain
- Fast, slow, or pounding heartbeat
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, trouble urinating, asthma, blood or bone marrow problems, or an enzyme problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- This medicine may decrease the amount of sperm a man makes and affect his ability to have children while using this medicine. If you are a man who plans to have children, talk with your doctor first.
- This medicine may cause the following problems.Liver problemsAnemia or other blood problemsSerious infectionsHeart problems, including myocarditis, pericarditisSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP)
- Your skin or urine may turn orange or yellow while you are using this medicine. This is normal and nothing to worry about.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- This medicine may decrease the amount of sperm men make and affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Sulfasalazine Coupons & Prices
sulfaSALAzine 500MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
If you are searching for a sulfasalazine coupon, the good news is that sulfasalazine is already available as a low-cost generic (the brand versions are sold as Azulfidine and Azulfidine EN-tabs). Cash prices still vary widely from one pharmacy to the next, so it pays to compare before you fill. Enter your ZIP above to see today's price at pharmacies near you and to pull up a free Rx.com discount coupon you can show at the counter.
What is sulfasalazine and how does it work?
Sulfasalazine is an anti-inflammatory medicine that also acts as a disease-modifying antirheumatic drug (DMARD). It belongs to the aminosalicylate and sulfonamide classes. In the gut it is broken down into two parts, one related to aspirin (an aminosalicylate) and one a sulfa antibiotic, which together calm inflammation in the bowel and the joints.
It is FDA-approved to treat ulcerative colitis and to help keep it in remission. The delayed-release form (EN-tabs) is also approved for rheumatoid arthritis in adults who did not respond well enough to other treatments, and for polyarticular juvenile idiopathic arthritis in children. Doctors sometimes prescribe it for other inflammatory conditions as well; always follow your own prescriber's instructions.
Sulfasalazine cost and coupons without insurance
Sulfasalazine is an older, widely stocked generic, so it is usually one of the more affordable prescriptions in its category even if you pay cash. That said, the price for the same tablets can differ a lot between a large chain, a grocery pharmacy, and an independent store, which is exactly why comparing is worth your time. Rx.com checks prices across more than 60,000 pharmacies nationwide so you can see who is lowest near you.
To find your price, enter your ZIP above. You will see current cash prices and a free Rx.com discount coupon you can use whether or not you have insurance. There is no manufacturer copay savings card for sulfasalazine, so a pharmacy discount coupon is often the simplest way to lower an out-of-pocket cost.
Sulfasalazine vs. related medicines
Sulfasalazine is one of several options for inflammatory bowel disease and inflammatory arthritis, and the right choice depends on your condition and history. For ulcerative colitis, aminosalicylate alternatives include mesalamine and balsalazide, which do not contain the sulfa component and may be options for people who cannot tolerate it.
For rheumatoid arthritis and related joint conditions, sulfasalazine is often compared with other DMARDs such as methotrexate, hydroxychloroquine, and leflunomide. These work in different ways and are sometimes combined. Only your prescriber can decide which is appropriate for you, but you can compare cash prices for each on Rx.com.
Safety and side effects to know
Sulfasalazine does not carry an FDA boxed warning, but it does have serious risks your care team will watch for. These include blood problems such as agranulocytosis, aplastic anemia, and low white blood cell counts; severe hypersensitivity and skin reactions such as Stevens-Johnson syndrome, DRESS, and toxic epidermal necrolysis; and liver injury. Because of this, doctors order periodic blood counts (CBC with differential) and liver function tests while you take it. A common and harmless effect is a yellow-orange color of the urine and skin; the medicine can also make you more sensitive to sunlight.
Sulfasalazine should not be used by people with a known allergy to sulfa (sulfonamide) or salicylate medicines, or by those with intestinal or urinary blockage or porphyria. It can trigger red-blood-cell breakdown in people with G6PD deficiency and may temporarily lower a man's sperm count, which usually reverses after stopping. This is general information, not medical advice, so review your full history and any other medicines with your doctor or pharmacist.
This Sulfasalazine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Sulfasalazine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.