Zyrtec-D Allergy & Congestion
ZyrTEC-D Allergy & Congestion 24 Tablets Extended Release 12 Hour
What is Zyrtec-D Allergy & Congestion?
ZyrTEC-D Allergy & Congestion is a medication that combines two ingredients to help relieve allergy symptoms and nasal congestion. It is used to treat conditions like hay fever and sinus pressure.Side Effects
- Nausea, vomiting, loss of appetite, pain in the upper stomach
- Unusual behavior
- Severe restlessness, nervousness, dizziness, or trouble sleeping
Warnings
- Yellow skin or eyes
- Unusual behavior
- Seizures
- Severe restlessness, nervousness, dizziness, or trouble sleeping
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Prescription savings · · · ·
What is Zyrtec-D Allergy & Congestion ?
ZyrTEC-D Allergy & Congestion is a medication that combines two ingredients to help relieve allergy symptoms and nasal congestion. It is used to treat conditions like hay fever and sinus pressure.- Nausea, vomiting, loss of appetite, pain in the upper stomach
- Unusual behavior
- Severe restlessness, nervousness, dizziness, or trouble sleeping
- Chest pain, fast heartbeat, lightheadedness or fainting
- Dark-colored urine or pale stools
- Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
- Yellow skin or eyes
- Seizures
- Yellow skin or eyes
- Unusual behavior
- Seizures
- Severe restlessness, nervousness, dizziness, or trouble sleeping
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Dark-colored urine or pale stools
- Nausea, vomiting, loss of appetite, pain in the upper stomach
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, high blood pressure, diabetes, heart disease, high pressure inside your eye, overactive thyroid, problems with urination, or prostate problems, or if you are on dialysis.
Zyrtec-D Allergy & Congestion Coupons & Prices
ZyrTEC-D Allergy & Congestion 24 Tablets Extended Release 12 Hour
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Looking for a Zyrtec-D Allergy & Congestion coupon? Zyrtec-D is an over-the-counter allergy and congestion tablet that combines cetirizine (a second-generation antihistamine that is less sedating than older antihistamines but may cause drowsiness in some people) with pseudoephedrine (a nasal decongestant) to relieve congestion, sinus pressure, sneezing, runny nose, and itchy, watery eyes. Because it contains pseudoephedrine, it is sold from behind the pharmacy counter, but you do not need a prescription to buy it. Enter your ZIP above to see today's price at pharmacies near you, and use an Rx.com coupon to help lower your out-of-pocket cost.
What is Zyrtec-D and how does it work?
Zyrtec-D (generic name cetirizine hydrochloride / pseudoephedrine hydrochloride) is an over-the-counter combination medicine for upper respiratory allergy and cold symptoms in adults and children 12 years and older. It is also sold as Zyrtec-D 12 Hour and Zyrtec-D Allergy & Congestion. Each extended-release tablet pairs two medicines that work in different ways: cetirizine is a second-generation antihistamine (an H1 blocker) that calms the allergic symptoms and is less sedating than older antihistamines, though it may still cause drowsiness in some people, while pseudoephedrine is a nasal decongestant (a sympathomimetic amine) that shrinks swollen nasal passages.
Together they relieve nasal and sinus congestion, sinus pressure, sneezing, runny nose, itchy or watery eyes, and itching of the nose or throat. The standard tablet contains 5 mg of cetirizine and 120 mg of pseudoephedrine, taken as one tablet every 12 hours, with a maximum of 2 tablets in 24 hours. A generic version of this combination is available. Always follow the directions on the package label.
How to save on Zyrtec-D with an Rx.com coupon
Even though Zyrtec-D is available without a prescription, the price can differ a lot from one pharmacy to the next, and some over-the-counter items are cheaper with a coupon or when your provider writes a prescription for them. An Rx.com discount coupon can help lower what you pay at the register. Prices change often and are shown live on this page, so enter your ZIP above to see today's price at pharmacies near you and compare before you buy.
Zyrtec-D does not have a manufacturer savings or copay card. You can learn more about the brand product at the manufacturer's official Zyrtec website, though any store or brand offers and their terms vary. Because pseudoephedrine is kept behind the pharmacy counter, plan to ask the pharmacy staff for it and bring a photo ID.
Zyrtec-D compared to other allergy and congestion options
Zyrtec-D is one of several antihistamine-plus-decongestant products. If you have congestion along with allergy symptoms, similar combination options include Claritin-D (loratadine with pseudoephedrine) and Allegra-D (fexofenadine with pseudoephedrine). All of these are sold from behind the pharmacy counter because of the pseudoephedrine component.
If you do not need a decongestant, the antihistamine alone may be enough. The cetirizine in Zyrtec-D is the same active ingredient found in Zyrtec and in generic cetirizine, which treat allergy symptoms without the decongestant. If congestion is your main complaint, a stand-alone decongestant such as Sudafed or generic pseudoephedrine is another option. A pharmacist can help you choose based on your symptoms and health history.
Safety and who should be careful with Zyrtec-D
Zyrtec-D has no FDA boxed warning, but the pseudoephedrine component can raise blood pressure and heart rate, so it is not right for everyone. Do not use it if you have ever had an allergic reaction to cetirizine, hydroxyzine, or pseudoephedrine, and do not use it with, or within two weeks of stopping, an MAO inhibitor. Do not give it to children under 12. Ask a doctor before using it if you have heart disease, high blood pressure, thyroid disease, diabetes, glaucoma, trouble urinating due to an enlarged prostate, or kidney or liver disease, and ask a doctor before use if you are pregnant or breastfeeding.
Stop use and see a doctor if you have nervousness, dizziness, or sleeplessness, or if your symptoms do not improve within 7 days or occur with a fever. Do not exceed the recommended dose, because an overdose can cause serious heart and blood-vessel effects; if an overdose is suspected, contact Poison Control at 1-800-222-1222. Cetirizine may cause drowsiness in some people, so use caution with alcohol and other medicines that make you sleepy, and be careful when driving or operating machinery until you know how it affects you. This information is not medical advice, so talk with your doctor or pharmacist about what is right for you.
This Zyrtec-D Allergy & Congestion information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Zyrtec-D Allergy & Congestion on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.