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Zyrtec-D Allergy & Congestion

ZyrTEC-D Allergy & Congestion 24 Tablets Extended Release 12 Hour

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What is Zyrtec-D Allergy & Congestion?

ZyrTEC-D Allergy & Congestion is a medication that combines two ingredients to help relieve allergy symptoms and nasal congestion. It is used to treat conditions like hay fever and sinus pressure.

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What is Zyrtec-D Allergy & Congestion ?

ZyrTEC-D Allergy & Congestion is a medication that combines two ingredients to help relieve allergy symptoms and nasal congestion. It is used to treat conditions like hay fever and sinus pressure.

Source: MedlinePlus, U.S. National Library of Medicine

  • Nausea, vomiting, loss of appetite, pain in the upper stomach
  • Unusual behavior
  • Severe restlessness, nervousness, dizziness, or trouble sleeping
  • Chest pain, fast heartbeat, lightheadedness or fainting
  • Dark-colored urine or pale stools
  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
  • Yellow skin or eyes
  • Seizures
  • Yellow skin or eyes
  • Unusual behavior
  • Seizures
  • Severe restlessness, nervousness, dizziness, or trouble sleeping
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Dark-colored urine or pale stools
  • Nausea, vomiting, loss of appetite, pain in the upper stomach
  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, high blood pressure, diabetes, heart disease, high pressure inside your eye, overactive thyroid, problems with urination, or prostate problems, or if you are on dialysis.
What is the difference between Zyrtec and Zyrtec-D?
Zyrtec contains only cetirizine, an antihistamine that treats allergy symptoms such as sneezing, runny nose, and itchy, watery eyes. Zyrtec-D contains the same cetirizine plus pseudoephedrine, a decongestant that also relieves nasal and sinus congestion and sinus pressure. Because of the pseudoephedrine, Zyrtec-D is kept behind the pharmacy counter, while plain Zyrtec can be picked off the shelf. Choose Zyrtec-D if congestion is part of your symptoms.
How long does it take for Zyrtec-D to start working?
Zyrtec-D is an extended-release tablet designed to work over a 12-hour period, and many people begin to feel relief within about an hour of taking a dose. It is taken as one tablet every 12 hours, with no more than 2 tablets in 24 hours. If your symptoms do not improve within 7 days, or if they come with a fever, stop use and see a doctor.
Can you take Zyrtec-D every day?
Zyrtec-D is intended for short-term relief of allergy and congestion symptoms. Because it contains a decongestant that can raise blood pressure and heart rate, it should not be used longer than needed. If your symptoms last more than 7 days, or if you feel you need it every day for a long time, talk with your doctor before continuing. People with heart disease, high blood pressure, thyroid disease, diabetes, glaucoma, prostate problems, or kidney or liver disease should ask a doctor before using it at all.
Why is Zyrtec-D kept behind the pharmacy counter?
Zyrtec-D contains pseudoephedrine, which is regulated under the federal Combat Methamphetamine Epidemic Act. That law requires products with pseudoephedrine to be stored behind the pharmacy counter, and buyers must show a photo ID and stay within purchase-quantity limits. You still do not need a prescription; you simply ask the pharmacy staff for it.
Does Zyrtec-D make you sleepy or keep you awake?
It can go either way for different people. Cetirizine is a second-generation antihistamine that is less sedating than older antihistamines, but it still causes drowsiness in some people. In fact, Zyrtec-D is not labeled non-drowsy, and its Drug Facts label cautions you to be careful when driving or operating machinery. The pseudoephedrine, on the other hand, is a stimulant-type decongestant that can cause nervousness, sleeplessness, or a wound-up feeling. Use caution with alcohol and other sedating medicines, and stop use and see a doctor if you have nervousness, dizziness, or sleeplessness.
How much does Zyrtec-D Allergy & Congestion cost without insurance?
The price of Zyrtec-D Allergy & Congestion without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Zyrtec-D Allergy & Congestion?
Common side effects of Zyrtec-D Allergy & Congestion may include: Nausea, vomiting, loss of appetite, pain in the upper stomach, Unusual behavior, Severe restlessness, nervousness, dizziness, or trouble sleeping, Chest pain, fast heartbeat, lightheadedness or fainting, Dark-colored urine or pale stools. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Zyrtec-D Allergy & Congestion?
Generic versions may be available for Zyrtec-D Allergy & Congestion. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Zyrtec-D Allergy & Congestion on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Zyrtec-D Allergy & Congestion?
The cheapest pharmacy for Zyrtec-D Allergy & Congestion depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Zyrtec-D Allergy & Congestion near you.

Zyrtec-D Allergy & Congestion Coupons & Prices

ZyrTEC-D Allergy & Congestion 24 Tablets Extended Release 12 Hour

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Zyrtec-D Allergy & Congestion Box — prescription drug image
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Looking for a Zyrtec-D Allergy & Congestion coupon? Zyrtec-D is an over-the-counter allergy and congestion tablet that combines cetirizine (a second-generation antihistamine that is less sedating than older antihistamines but may cause drowsiness in some people) with pseudoephedrine (a nasal decongestant) to relieve congestion, sinus pressure, sneezing, runny nose, and itchy, watery eyes. Because it contains pseudoephedrine, it is sold from behind the pharmacy counter, but you do not need a prescription to buy it. Enter your ZIP above to see today's price at pharmacies near you, and use an Rx.com coupon to help lower your out-of-pocket cost.

What is Zyrtec-D and how does it work?

Zyrtec-D (generic name cetirizine hydrochloride / pseudoephedrine hydrochloride) is an over-the-counter combination medicine for upper respiratory allergy and cold symptoms in adults and children 12 years and older. It is also sold as Zyrtec-D 12 Hour and Zyrtec-D Allergy & Congestion. Each extended-release tablet pairs two medicines that work in different ways: cetirizine is a second-generation antihistamine (an H1 blocker) that calms the allergic symptoms and is less sedating than older antihistamines, though it may still cause drowsiness in some people, while pseudoephedrine is a nasal decongestant (a sympathomimetic amine) that shrinks swollen nasal passages.

Together they relieve nasal and sinus congestion, sinus pressure, sneezing, runny nose, itchy or watery eyes, and itching of the nose or throat. The standard tablet contains 5 mg of cetirizine and 120 mg of pseudoephedrine, taken as one tablet every 12 hours, with a maximum of 2 tablets in 24 hours. A generic version of this combination is available. Always follow the directions on the package label.

How to save on Zyrtec-D with an Rx.com coupon

Even though Zyrtec-D is available without a prescription, the price can differ a lot from one pharmacy to the next, and some over-the-counter items are cheaper with a coupon or when your provider writes a prescription for them. An Rx.com discount coupon can help lower what you pay at the register. Prices change often and are shown live on this page, so enter your ZIP above to see today's price at pharmacies near you and compare before you buy.

Zyrtec-D does not have a manufacturer savings or copay card. You can learn more about the brand product at the manufacturer's official Zyrtec website, though any store or brand offers and their terms vary. Because pseudoephedrine is kept behind the pharmacy counter, plan to ask the pharmacy staff for it and bring a photo ID.

Zyrtec-D compared to other allergy and congestion options

Zyrtec-D is one of several antihistamine-plus-decongestant products. If you have congestion along with allergy symptoms, similar combination options include Claritin-D (loratadine with pseudoephedrine) and Allegra-D (fexofenadine with pseudoephedrine). All of these are sold from behind the pharmacy counter because of the pseudoephedrine component.

If you do not need a decongestant, the antihistamine alone may be enough. The cetirizine in Zyrtec-D is the same active ingredient found in Zyrtec and in generic cetirizine, which treat allergy symptoms without the decongestant. If congestion is your main complaint, a stand-alone decongestant such as Sudafed or generic pseudoephedrine is another option. A pharmacist can help you choose based on your symptoms and health history.

Safety and who should be careful with Zyrtec-D

Zyrtec-D has no FDA boxed warning, but the pseudoephedrine component can raise blood pressure and heart rate, so it is not right for everyone. Do not use it if you have ever had an allergic reaction to cetirizine, hydroxyzine, or pseudoephedrine, and do not use it with, or within two weeks of stopping, an MAO inhibitor. Do not give it to children under 12. Ask a doctor before using it if you have heart disease, high blood pressure, thyroid disease, diabetes, glaucoma, trouble urinating due to an enlarged prostate, or kidney or liver disease, and ask a doctor before use if you are pregnant or breastfeeding.

Stop use and see a doctor if you have nervousness, dizziness, or sleeplessness, or if your symptoms do not improve within 7 days or occur with a fever. Do not exceed the recommended dose, because an overdose can cause serious heart and blood-vessel effects; if an overdose is suspected, contact Poison Control at 1-800-222-1222. Cetirizine may cause drowsiness in some people, so use caution with alcohol and other medicines that make you sleepy, and be careful when driving or operating machinery until you know how it affects you. This information is not medical advice, so talk with your doctor or pharmacist about what is right for you.

Sources & accuracy

This Zyrtec-D Allergy & Congestion information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Zyrtec-D Allergy & Congestion on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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