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Colesevelam Hcl

Colesevelam HCl 625MG

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What is Colesevelam Hcl?

Colesevelam is a medication used to lower cholesterol levels and help control blood sugar in adults with type 2 diabetes. It works by binding bile acids in the intestines, which helps remove them from the body.

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What is Colesevelam Hcl ?

Colesevelam is a medication used to lower cholesterol levels and help control blood sugar in adults with type 2 diabetes. It works by binding bile acids in the intestines, which helps remove them from the body.

Source: MedlinePlus, U.S. National Library of Medicine

  • Trouble swallowing
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches
  • Headache, dizziness, lightheadedness, blurred vision
  • Sudden and severe stomach pain, nausea, vomiting, severe constipation, dark urine, yellow skin or eyes
  • Weakness, confusion, drowsiness, increased hunger, fast heartbeat, shakiness
  • Tell your doctor if you are pregnant or breastfeeding, or if you have trouble swallowing, digestion problems (including ongoing problems with constipation), phenylketonuria (PKU), or a history of vitamin A, D, E, or K deficiency. Tell your doctor if you had stomach or bowel surgery.
  • This medicine may cause the following problems:Pancreatitis (swelling of the pancreas)Stomach or bowel blockageHypertriglyceridemia (high fat levels in the blood), which may cause serious heart problems
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor may check your triglycerides or fatty acids in the blood before using this medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Trouble swallowing
  • Weakness, confusion, drowsiness, increased hunger, fast heartbeat, or shakiness
What is colesevelam (Welchol) used for?
Colesevelam is FDA-approved as an add-on to diet and exercise to lower elevated LDL ("bad") cholesterol in adults and in children ages 10 to 17 with heterozygous familial hypercholesterolemia, and to improve blood sugar control (lower A1C) in adults with type 2 diabetes. It is often added when a statin alone is not enough. It is not used for type 1 diabetes and is not a first-line replacement for statins.
Is colesevelam the same as Welchol?
Yes. Colesevelam hydrochloride is the generic name for the medicine sold under the brand name Welchol. They contain the same active ingredient and work the same way. When it is in stock, the generic is usually less expensive than the brand, though both the brand and generic have had intermittent supply disruptions.
How does colesevelam lower both cholesterol and blood sugar?
Colesevelam binds bile acids in the intestine and removes them from the body. To replace them, the liver uses up cholesterol from the blood, which lowers LDL cholesterol. Through its effects on bile acid signaling, colesevelam also helps improve blood sugar control and lower A1C in people with type 2 diabetes, though the exact mechanism for the glucose effect is not fully understood.
What are the most common side effects of colesevelam?
The most common side effects are constipation and indigestion (dyspepsia). It can also raise triglyceride levels in some people. Talk to your doctor or pharmacist if side effects bother you or do not go away.
How should I take colesevelam with my other medications?
Colesevelam can reduce how well your body absorbs certain oral medicines, such as levothyroxine, glyburide, oral contraceptives, phenytoin, and cyclosporine. To avoid this, those medicines should generally be taken at least 4 hours before colesevelam. Give your pharmacist your full medication list so they can check timing and interactions.
How much does Colesevelam Hcl cost without insurance?
The price of Colesevelam Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Colesevelam Hcl?
Common side effects of Colesevelam Hcl may include: Trouble swallowing, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fever, chills, cough, runny or stuffy nose, sore throat, body aches, Headache, dizziness, lightheadedness, blurred vision, Sudden and severe stomach pain, nausea, vomiting, severe constipation, dark urine, yellow skin or eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Colesevelam Hcl?
Generic versions may be available for Colesevelam Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Colesevelam Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Colesevelam Hcl?
The cheapest pharmacy for Colesevelam Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Colesevelam Hcl near you.

Colesevelam Hcl Coupons & Prices

Colesevelam HCl 625MG

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Colesevelam Hcl Tablet — prescription drug image
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Looking for a colesevelam HCl coupon? Colesevelam hydrochloride is the generic form of Welchol, a bile acid sequestrant that helps lower LDL ("bad") cholesterol and improve blood sugar control in adults with type 2 diabetes. When it is in stock, the generic is usually priced lower than the brand, but both Welchol and generic colesevelam have seen intermittent supply disruptions, so availability and cash price can vary widely from one pharmacy to the next. Enter your ZIP above to see today's price and compare colesevelam across more than 60,000 U.S. pharmacies with a free Rx.com coupon.

What is colesevelam and how does it work?

Colesevelam hydrochloride (brand name Welchol) belongs to a class of medicines called bile acid sequestrants. It works in the intestine, where it binds to bile acids and carries them out of the body. To replace the lost bile acids, the liver pulls cholesterol out of the blood to make more, which lowers LDL cholesterol. Through effects on bile acid signaling, colesevelam can also help lower A1C (a measure of long-term blood sugar).

It is FDA-approved as an add-on to diet and exercise to reduce elevated LDL cholesterol in adults and in boys and postmenarchal girls ages 10 to 17 with heterozygous familial hypercholesterolemia (an inherited high-cholesterol condition), and to improve glycemic control in adults with type 2 diabetes. Doctors often add it when a statin alone is not enough. It is not a first-line replacement for statins and is not used for type 1 diabetes.

How much does colesevelam cost without insurance?

When it is available, generic colesevelam is usually less expensive than brand-name Welchol, but there is no single "list price" and supply of both the brand and the generic has been intermittent. What you pay at the counter depends heavily on which pharmacy you use, whether your form is in stock, the dose form (tablets or oral suspension packets), and your ZIP code, so the same prescription can cost noticeably more at one store than another nearby. That is why comparing before you fill matters.

Rx.com shows live cash prices across more than 60,000 pharmacies and gives you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you. If you were prescribed brand-name Welchol specifically, its manufacturer runs an official savings program on the Welchol website; program eligibility and terms vary, so check the details there.

Colesevelam alternatives and related medications

Colesevelam is one of several cholesterol-lowering options, and it is common to compare it with other bile acid sequestrants and lipid-lowering drugs. Your prescriber chooses based on your cholesterol levels, whether you also have type 2 diabetes, and how you tolerate each option.

You can compare cash prices for any of these on Rx.com. This is general information, not a recommendation to switch; talk with your provider or pharmacist about which medicine fits your situation.

Safety and important precautions

Colesevelam has no boxed warning, but it is not right for everyone. It should not be used by people with a history of bowel obstruction, serum triglycerides over 500 mg/dL, or a history of pancreatitis caused by high triglycerides. Because it can raise triglyceride levels, extra caution is needed if your triglycerides are in the 300 to 500 mg/dL range. It can also worsen trouble swallowing or other gut-motility problems, and it has not been studied in severe GI disorders or after major GI surgery.

Common side effects include constipation and indigestion (dyspepsia). Colesevelam can reduce the absorption of fat-soluble vitamins and of several oral medicines, including levothyroxine, glyburide, oral contraceptives, phenytoin, and cyclosporine, so those should generally be taken at least 4 hours before colesevelam. This is not medical advice; share your full medication list with your doctor or pharmacist and follow their guidance.

Sources & accuracy

This Colesevelam Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Colesevelam Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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