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Chlorthalidone

Chlorthalidone 25MG

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What is Chlorthalidone?

Chlorthalidone is a generic drug used to treat edema and hypertension. The average Chlorthalidone price is about $31 for a supply of 30, 25 mg tablets. You can use our Rx.com savings offer to get an average Chlorthalidone discount of up to 80% off of the retail price at participating pharmacies near you.

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What is Chlorthalidone ?

Chlorthalidone is a generic drug used to treat edema and hypertension. The average Chlorthalidone price is about $31 for a supply of 30, 25 mg tablets. You can use our Rx.com savings offer to get an average Chlorthalidone discount of up to 80% off of the retail price at participating pharmacies near you.
  • Fever chills, cough, hoarseness
  • Yellow eyes or skin
  • Dry mouth, increased thirst, muscle cramps, nausea or vomiting
  • Unusual bleeding or bruising
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blood in the urine or stools, lower back or side pain, trouble urinating
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in the hands, feet, or lips
  • Lightheadedness, dizziness, fainting
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, heart failure, diabetes, gout, lupus, pancreas problems, or trouble urinating. Tell your doctor if you are on a low-salt diet.
  • This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Skin rash or itching
  • Unusual bleeding or bruising
  • Yellow eyes or skin
What is chlorthalidone used for?
Chlorthalidone is FDA-approved to manage high blood pressure, alone or with other blood-pressure medicines, and it is a recommended first-line option for hypertension. It is also approved as add-on therapy for edema (fluid swelling) related to congestive heart failure, liver cirrhosis, corticosteroid or estrogen therapy, and certain kidney conditions.
Is chlorthalidone better than hydrochlorothiazide?
They are both thiazide-type diuretics used for high blood pressure. Chlorthalidone lasts longer in the body and is more potent per milligram, which can mean stronger blood-pressure control but also more noticeable effects on electrolytes. Neither is right for everyone, so your prescriber decides which fits your situation.
What are the most common side effects of chlorthalidone?
Common effects come from removing salt and water, and include low potassium, low sodium, low magnesium, dehydration, and dizziness or fainting when standing up. It may also raise blood sugar, uric acid (which can trigger gout), and cholesterol, and can make skin more sensitive to sunlight. Report bothersome or severe symptoms to your provider.
Should chlorthalidone be taken in the morning or at night?
Because it is a diuretic that increases urination, it is generally taken in the morning so trips to the bathroom do not disrupt sleep. Follow the exact timing your prescriber or pharmacist gives you, and take it consistently at the same time each day.
Does chlorthalidone make you lose potassium?
Yes, chlorthalidone can lower potassium (hypokalemia) along with other electrolytes like sodium and magnesium. Providers often check your electrolytes and kidney function, and may suggest dietary changes or potassium monitoring. Tell your provider about symptoms like muscle cramps, weakness, or an irregular heartbeat.
How much does Chlorthalidone cost without insurance?
The price of Chlorthalidone without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 28% off retail prices with a free Rx.com coupon.
What are the common side effects of Chlorthalidone?
Common side effects of Chlorthalidone may include: Fever chills, cough, hoarseness, Yellow eyes or skin, Dry mouth, increased thirst, muscle cramps, nausea or vomiting, Unusual bleeding or bruising, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Chlorthalidone?
Generic versions may be available for Chlorthalidone. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Chlorthalidone on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Chlorthalidone?
The cheapest pharmacy for Chlorthalidone depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Chlorthalidone near you.

Chlorthalidone Coupons & Prices

Chlorthalidone 25MG

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Chlorthalidone Tablet — prescription drug image
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Looking for a chlorthalidone coupon? Chlorthalidone is an FDA-approved, widely used generic diuretic ("water pill") for high blood pressure, and being a generic it is already one of the more affordable blood-pressure medicines. Even so, the cash price can vary a lot from one pharmacy to the next, which is exactly why comparing matters. Enter your ZIP above to see today's price and a free Rx.com discount coupon accepted at more than 60,000 pharmacies nationwide.

What is chlorthalidone and how does it work?

Chlorthalidone is a thiazide-like diuretic (a monosulfamyl, sulfonamide-derived "water pill"). It helps your kidneys remove extra salt and water from the body, which lowers blood pressure and reduces fluid buildup. It is FDA-approved to manage high blood pressure (hypertension), on its own or alongside other blood-pressure medicines, and it is recommended as a first-line option for hypertension.

Chlorthalidone is also approved as add-on (adjunctive) therapy for edema (fluid swelling) linked to congestive heart failure, liver cirrhosis, and corticosteroid or estrogen therapy, and for edema from kidney conditions such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. It is longer-acting and more potent per milligram than hydrochlorothiazide.

Chlorthalidone cost and coupon savings without insurance

Chlorthalidone is available as an FDA-approved generic, so it is typically an inexpensive medication. It was originally sold under the brand Thalitone; the older brand Hygroton has been discontinued. Because there is a marketed generic, most people do not need a brand-name product to save.

Even for a low-cost generic, cash prices swing widely between pharmacies, so it pays to compare before you fill. Rx.com checks prices across more than 60,000 pharmacies and gives you a free discount coupon you can use with or without insurance. Enter your ZIP above to see today's price near you. There is no manufacturer copay savings card for generic chlorthalidone, so a discount coupon is usually the simplest way to lower the cash price.

Chlorthalidone vs. hydrochlorothiazide and other alternatives

Chlorthalidone is often compared with hydrochlorothiazide, another common thiazide-type diuretic. Chlorthalidone lasts longer in the body and is more potent per milligram, which can mean stronger blood-pressure lowering but also more pronounced effects on electrolytes. Other thiazide-like diuretics include indapamide and metolazone.

Blood pressure is often treated with medicines from other classes as well, such as the ACE inhibitor lisinopril, the ARB losartan, or the calcium channel blocker amlodipine. These are not interchangeable, and the right choice depends on your health history. Your prescriber can tell you which fits you best.

Safety, side effects, and what to watch for

Chlorthalidone has no boxed warning, but because it removes salt and water it can disturb your body's electrolytes and fluid balance. Possible effects include low potassium, low sodium, low magnesium, and hypochloremic alkalosis, along with dehydration and orthostatic hypotension (dizziness or fainting when standing up). It may also raise blood sugar, uric acid (which can trigger gout), and cholesterol or triglycerides, and it can make your skin more sensitive to sunlight. Because it is longer-acting and more potent than hydrochlorothiazide, these electrolyte effects can be more pronounced, so providers usually monitor electrolytes and kidney function.

Chlorthalidone should not be used by people who are not producing urine (anuria) or who are allergic to sulfonamides. Rare but serious risks include acute angle-closure glaucoma and severe skin reactions. This is general information, not medical advice, so tell your provider about your other medicines and health conditions and follow their guidance.

Sources & accuracy

This Chlorthalidone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Chlorthalidone on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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