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Divalproex Sodium Er Tablet — prescription drug image

Divalproex Sodium Er

Divalproex Sodium ER 500MG

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What is Divalproex Sodium Er?

Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Divalproex Sodium Er ?

Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.
  • nausea
  • drowsiness
  • dizziness
  • vomiting
  • weakness
  • tremor
  • hair loss
  • weight gain
  • blurred or double vision
  • may cause liver damage
  • risk of pancreatitis
  • can cause serious birth defects
  • may increase suicidal thoughts or actions
  • potential for serious skin reactions
  • monitor blood count and liver function regularly
  • may interact with other medications
What is Depakote ER used for?
Depakote ER (divalproex sodium extended-release) is FDA-approved to treat acute manic or mixed episodes of bipolar disorder, to help prevent migraine headaches, and to treat complex partial seizures and simple or complex absence seizures in people 10 years and older, either alone or with other medicines. It is a valproate anticonvulsant that also acts as a mood stabilizer.
What is the difference between Depakote ER and Depakote DR?
Both contain the same active valproate ingredient (divalproex sodium), but Depakote ER is extended-release and is usually taken once daily, while Depakote DR is delayed-release and is often taken more than once a day. The two forms are absorbed differently and are not equivalent milligram-for-milligram, so you should never switch between them without your prescriber adjusting the dose.
Is there a generic version of Depakote ER?
Yes. Depakote ER is available as a generic, divalproex sodium extended-release. The generic contains the same active ingredient and is typically much less expensive than the brand, so it is usually the biggest way to lower your cost. Enter your ZIP above to compare brand and generic prices near you.
What are the most serious side effects of Depakote ER?
Depakote ER has an FDA boxed warning for three life-threatening risks: serious liver damage (which can be fatal, usually within the first six months), major birth defects if taken during pregnancy, and pancreatitis. It can also cause high blood ammonia with confusion, low platelet counts, and suicidal thoughts. Because of these risks, doctors monitor liver function, blood counts, and ammonia. Call your doctor right away about severe stomach pain, vomiting, yellowing skin or eyes, unusual tiredness, or mood changes.
Why is Depakote ER dangerous during pregnancy?
Valproate medicines like Depakote ER can cause major birth defects, including neural tube defects such as spina bifida, and can lower a child's IQ when taken during pregnancy. Because of this, Depakote ER is contraindicated for migraine prevention in pregnancy and should not be used by women who can become pregnant unless it is clearly essential and other options have failed. If you could become pregnant, talk with your doctor about reliable contraception and safer alternatives.
How much does Divalproex Sodium Er cost without insurance?
The price of Divalproex Sodium Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Divalproex Sodium Er?
Common side effects of Divalproex Sodium Er may include: nausea, drowsiness, dizziness, vomiting, weakness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Divalproex Sodium Er?
Generic versions may be available for Divalproex Sodium Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Divalproex Sodium Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Divalproex Sodium Er?
The cheapest pharmacy for Divalproex Sodium Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Divalproex Sodium Er near you.

Divalproex Sodium Er Coupons & Prices

Divalproex Sodium ER 500MG

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Licensed US providers · Online visit in minutes
Divalproex Sodium Er Tablet — prescription drug image
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Divalproex Sodium Er 500mg (60)
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Looking for a Depakote ER coupon? Depakote ER (divalproex sodium, extended-release) is a brand-name valproate medicine used as a mood stabilizer for bipolar mania, to help prevent migraine headaches, and to treat certain types of seizures. Whether you have insurance, Medicare, or no coverage at all, you can use a free Rx.com cash coupon at the pharmacy counter. Enter your ZIP above to see today's price on both the brand and its lower-cost generic in your area.

What is Depakote ER and how does it work?

Depakote ER is the extended-release form of divalproex sodium, a valproate medicine that belongs to the anticonvulsant (anti-epileptic) family and also acts as a mood stabilizer. It is FDA-approved for the acute treatment of manic or mixed episodes of bipolar disorder (with or without psychotic features), for the prevention (prophylaxis) of migraine headaches, and for treating complex partial seizures as well as simple and complex absence seizures in patients 10 years and older, either on its own or added to other therapy.

The "ER" means the tablet releases the medicine slowly over the day, which usually allows once-daily dosing. Valproate is thought to work by increasing the calming brain chemical GABA and steadying overactive electrical signaling in the brain. Depakote ER is also sometimes prescribed off-label for other conditions; only your prescriber can decide whether it is right for you.

Depakote ER cost: manufacturer savings vs. the Rx.com cash coupon

The good news for cost is that Depakote ER has an FDA-approved generic, divalproex sodium extended-release, and the generic is typically the single biggest way to lower your bill. There is no widely available manufacturer copay card for Depakote ER, and any drugmaker copay card would generally require commercial (non-government) insurance anyway. AbbVie, the maker of Depakote, does run a patient assistance program through the AbbVie Patient Assistance Foundation for qualifying patients with limited income; you can look up that program on AbbVie's official website, and terms and eligibility vary.

An Rx.com cash coupon works differently: it is a discount you use instead of insurance, so it can help if you are uninsured, on Medicare (where copay cards are not allowed), or if a card is declined. Ask your pharmacist to run the Rx.com price and compare it against your insurance copay and the generic price, then use whichever is lower. Enter your ZIP above to see today's price at pharmacies near you.

Depakote ER vs. Depakote DR and other alternatives

Depakote comes in more than one form. Depakote (the delayed-release, or DR, tablet) and Depakote ER (extended-release) are not interchangeable milligram-for-milligram, so never switch between them without your prescriber's guidance. Both deliver the same active valproate ingredient but are absorbed differently, which affects dosing. Depakene and valproic acid are closely related valproate products.

Depending on the condition, a prescriber may consider other options. For seizures and mood stabilization, lamotrigine is a common alternative, and topiramate is used both for certain seizures and for migraine prevention. This is background information, not a recommendation; the right choice depends on your diagnosis and health history.

Important safety information

Depakote ER carries an FDA boxed warning for three serious risks. First, hepatotoxicity, including rare but sometimes fatal liver failure that most often occurs within the first six months; children under 2 and people with mitochondrial disorders (such as POLG mutations) are at highest risk. Second, fetal risk: valproate can cause major birth defects, including neural tube defects (spina bifida), and lower IQ in children exposed before birth. It is contraindicated for migraine prevention in pregnancy and should not be used in women who can become pregnant unless clearly essential. Third, pancreatitis, including rare fatal cases.

Depakote ER is also contraindicated in people with urea cycle disorders and known mitochondrial disease, and it can cause high blood ammonia with confusion (hyperammonemic encephalopathy), low platelet counts, and suicidal thoughts. Doctors monitor liver function, blood counts and platelets, and ammonia during treatment. This is not medical advice; take Depakote ER exactly as prescribed, keep your lab appointments, and talk with your doctor or pharmacist about your personal risks before starting or stopping.

Sources & accuracy

This Divalproex Sodium Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Divalproex Sodium Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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