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Desloratadine

Desloratadine 5MG

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What is Desloratadine?

Clarinex is used to treat allergic rhinitis. The generic version of Clarinex is Desloratadine. The average price for Clarinex is around $269 for a supply of 30, 5 mg tablets. Use our Rx.com savings offer to get big discounts on Clarinex at participating pharmacies near you.

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What is Desloratadine ?

Clarinex is used to treat allergic rhinitis. The generic version of Clarinex is Desloratadine. The average price for Clarinex is around $269 for a supply of 30, 5 mg tablets. Use our Rx.com savings offer to get big discounts on Clarinex at participating pharmacies near you.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fast or irregular (uneven) heartbeat.
  • Pain when urinating, or trouble urinating.
  • Mild skin rash.
  • Muscle aches.
  • Yellowing of your skin or the whites of your eyes.
  • Pain when urinating, or trouble urinating.
  • Some forms of this medicine may contain phenylalanine (aspartame). Read the label before using this medicine. This is only a concern if you have a disorder called phenylketonuria (a problem with amino acids). If you have this condition, talk to your doctor before using this medicine.
  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have liver disease or kidney disease. Tell your doctor if you have a history of heart problems, and about any other medical problems you may have.
  • Yellowing of your skin or the whites of your eyes.
Is desloratadine (Clarinex) the same as loratadine (Claritin)?
They are closely related but not identical. Desloratadine is the active metabolite of loratadine, meaning it is the form your body converts loratadine into after you take it. Both are non-drowsy, once-daily antihistamines that work in a similar way. Some people find one works better for them than the other, and prices can differ, so it can be worth comparing both.
Does desloratadine make you sleepy or cause drowsiness?
Desloratadine is classified as a second-generation, non-sedating antihistamine, so it is much less likely to cause drowsiness than older allergy medicines. That said, drowsiness and fatigue are still listed among the possible side effects, so a small number of people may notice them. See how it affects you before driving or doing anything that needs full alertness.
Is desloratadine available over the counter or by prescription only?
In the United States, desloratadine (Clarinex) is a prescription medicine. This differs from some other second-generation antihistamines like loratadine and cetirizine, which are sold over the counter. You will need a prescription from your provider to fill desloratadine, and you can use an Rx.com discount coupon to help lower the cash price.
How long does desloratadine take to work and how long does it last?
Desloratadine is designed to be taken once a day, and its effects last around 24 hours, which is why a single daily dose is enough for most people. Many people notice symptom relief within a few hours of the first dose. For ongoing allergies, it is taken regularly to keep symptoms under control. Follow the dosing instructions from your provider.
Can you take desloratadine every day for chronic hives?
Yes. Desloratadine is FDA-approved to treat the itching and reduce the hives of chronic idiopathic urticaria in appropriate patients, and it is taken once daily. For an ongoing condition like chronic hives, your provider may have you take it every day. Always follow your provider's specific instructions on dose and how long to use it.
How much does Desloratadine cost without insurance?
The price of Desloratadine without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Desloratadine?
Common side effects of Desloratadine may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fast or irregular (uneven) heartbeat., Pain when urinating, or trouble urinating., Mild skin rash., Muscle aches.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Desloratadine?
Generic versions may be available for Desloratadine. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Desloratadine on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Desloratadine?
The cheapest pharmacy for Desloratadine depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Desloratadine near you.

Desloratadine Coupons & Prices

Desloratadine 5MG

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Looking for a desloratadine coupon? Desloratadine is the low-cost generic version of Clarinex, a once-daily, non-drowsy antihistamine used for seasonal and year-round allergies and chronic hives. Because it is a generic, the cash price is already modest, but what you actually pay can vary widely from one pharmacy to the next. Rx.com compares desloratadine prices across more than 60,000 pharmacies so you can find the lowest price near you and show a free discount coupon at the counter. Enter your ZIP above to see today's price.

What is desloratadine and how does it work?

Desloratadine is a second-generation, non-sedating H1 antihistamine and is the active metabolite of loratadine. It is sold under the brand name Clarinex, and Clarinex-D combines desloratadine with the decongestant pseudoephedrine. It works by blocking histamine, the natural substance your body releases during an allergic reaction, which helps calm sneezing, runny nose, itchy or watery eyes, and an itchy nose or throat.

The FDA has approved desloratadine to relieve the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 2 years and older, and of perennial (year-round) allergic rhinitis in patients 6 months and older. It is also approved to relieve itching and reduce hives in chronic idiopathic urticaria in patients 6 months and older. It is taken once daily. Clarinex-D is used when allergy symptoms come with nasal congestion.

How much does desloratadine cost without insurance?

Desloratadine is available as an FDA-approved generic, so it is generally one of the more affordable prescription allergy options, even if you are paying cash without insurance. The catch is that pharmacies set their own cash prices, and the difference between the highest and lowest price in the same town can be surprisingly large. That is why it pays to compare before you fill.

Rx.com checks desloratadine prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use whether or not you have insurance. There is no manufacturer savings card for desloratadine, so a pharmacy discount is usually the most reliable way to lower the cash price. Enter your ZIP above to see today's price near you.

Desloratadine vs. other antihistamines

Desloratadine is one of several non-drowsy, once-daily antihistamines, and the best choice often comes down to price and how your body responds. If desloratadine is not covered or not the cheapest option at your pharmacy, it is worth comparing prices on these related allergy medicines:

All of these are available as generics. Use the ZIP search above to compare the cash price of each and find the best value for you.

Safety and side effects

Desloratadine is generally well tolerated and has no boxed warning. The most common side effects are headache, dry mouth, fatigue, drowsiness, nausea, dizziness, and sore throat. Rare hypersensitivity reactions such as rash, itching, hives, swelling (angioedema), and anaphylaxis have been reported; get medical help right away if you notice signs of a serious allergic reaction. An overdose most often shows up as drowsiness.

If you have liver or kidney problems, your provider may recommend every-other-day dosing. The orally disintegrating tablets contain aspartame (a source of phenylalanine), which matters if you have phenylketonuria. Use caution during pregnancy or breastfeeding. This information is not medical advice, so talk with your doctor or pharmacist about your full health history and any other medicines you take before starting desloratadine.

Sources & accuracy

This Desloratadine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Desloratadine on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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