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Doxycycline Monohydrate Capsule — prescription drug image

Doxycycline Monohydrate

Doxycycline Monohydrate 100MG

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What is Doxycycline Monohydrate?

Mondoxyne NL is used to treat certain bacterial infections including acne. There is currently no generic version of Mondoxyne NL available in the United States. On average, the cost for 60, 50 mg Mondoxyne NL oral capsule monohydrate is around $75. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.

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What is Doxycycline Monohydrate ?

Mondoxyne NL is used to treat certain bacterial infections including acne. There is currently no generic version of Mondoxyne NL available in the United States. On average, the cost for 60, 50 mg Mondoxyne NL oral capsule monohydrate is around $75. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.
  • Diarrhea that may contain blood
  • Severe headache, dizziness, vision changes
  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches
  • Burning, pain, or irritation in your upper stomach or throat
  • Joint pain, unusual tiredness or weakness
  • Swollen, painful, or tender lymph glands in the neck, armpit, or groin, or yellow skin or eyes
  • Sudden and severe stomach pain, nausea, vomiting, lightheadedness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Birth control pills may not work as well when used together with this medicine. Use a second form of birth control to keep from getting pregnant.
  • Tell your doctor if you have kidney disease, liver disease, asthma, or an allergy to sulfites. Tell your doctor if you had surgery on your stomach, or if you have a history of yeast infections.
  • This medicine may cause the following problems:Permanent change in tooth color (in children younger than 8 years of age)Serious skin reactions, including exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS)Increased pressure inside the headYeast infectionImmune system problems
  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is doxycycline monohydrate used to treat?
Doxycycline monohydrate is a tetracycline antibiotic approved to treat a broad range of bacterial infections. These include certain respiratory tract infections (such as pneumonia from susceptible organisms), urinary tract infections, skin and soft-tissue infections, rickettsial infections like Rocky Mountain spotted fever, typhus, and Q fever, and sexually transmitted infections such as chlamydia. It's also used as an add-on therapy for inflammatory acne, to help prevent malaria, and to treat and prevent anthrax after exposure. It only works against bacterial infections, not viruses like colds or the flu.
What is the difference between doxycycline monohydrate and doxycycline hyclate?
Both are forms of the same antibiotic, doxycycline, just made with a different salt (monohydrate versus hyclate). They treat the same infections and work the same way in the body. The practical differences are in which brand-name products are available and, for some people, how well the stomach tolerates one versus the other. Your prescriber or pharmacist can tell you which form was prescribed and why.
How long does doxycycline monohydrate take to work?
Many people start to feel better within a few days of starting doxycycline, though the exact timing depends on the type and severity of the infection. For conditions like acne it can take longer, often several weeks, to see the full benefit. Even if you feel better quickly, finish the full course exactly as prescribed unless your provider tells you otherwise, so the infection is fully cleared and to help prevent antibiotic resistance.
Can you drink alcohol while taking doxycycline monohydrate?
It's best to check with your provider or pharmacist about alcohol while you're on doxycycline. Alcohol can worsen stomach upset and, especially with heavy or chronic use, may reduce how well the antibiotic works. Being ill and taking an antibiotic is also a good reason to go easy. Follow the specific guidance your provider gives you for your situation.
What foods and medicines should you avoid with doxycycline?
Antacids and supplements or products containing calcium, iron, or magnesium, as well as dairy, can bind to doxycycline and reduce how much of it your body absorbs, so separate them from your dose. Doxycycline may also make hormonal birth control less effective, so ask your provider about backup contraception. Take each dose with a full glass of water and stay upright to protect your throat and esophagus. Always tell your provider and pharmacist about all the medicines and supplements you take.
How much does Doxycycline Monohydrate cost without insurance?
The price of Doxycycline Monohydrate without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Doxycycline Monohydrate?
Common side effects of Doxycycline Monohydrate may include: Diarrhea that may contain blood, Severe headache, dizziness, vision changes, Fever, chills, cough, runny or stuffy nose, sore throat, body aches, Burning, pain, or irritation in your upper stomach or throat, Joint pain, unusual tiredness or weakness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Doxycycline Monohydrate?
Generic versions may be available for Doxycycline Monohydrate. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Doxycycline Monohydrate on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Doxycycline Monohydrate?
The cheapest pharmacy for Doxycycline Monohydrate depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Doxycycline Monohydrate near you.

Doxycycline Monohydrate Coupons & Prices

Doxycycline Monohydrate 100MG

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Doxycycline Monohydrate Capsule — prescription drug image
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Looking for a doxycycline monohydrate coupon? Doxycycline monohydrate is a widely used generic tetracycline antibiotic, and because it's generic it's already one of the lower-cost prescription antibiotics. Even so, the cash price can vary a lot from one pharmacy to the next, which is exactly why comparing pays off. Rx.com checks prices across more than 60,000 pharmacies so you can find a low cash price near you, no insurance required. Enter your ZIP above to see today's price at pharmacies in your area.

What is doxycycline monohydrate and how does it work?

Doxycycline monohydrate is a generic tetracycline-class antibiotic. It works by stopping bacteria from making the proteins they need to grow and multiply, which helps your body clear the infection. It's FDA-approved for a broad range of bacterial infections, including certain respiratory tract infections (such as pneumonia caused by susceptible organisms), urinary tract infections, skin and soft-tissue infections, rickettsial infections (like Rocky Mountain spotted fever, typhus, and Q fever), and several sexually transmitted infections (including chlamydia). It's also used as an adjunctive therapy for inflammatory acne, for malaria prevention (Plasmodium falciparum), and for the treatment and post-exposure prevention of anthrax.

Doxycycline is sold under several brand names, and which one you see depends partly on the salt form. The monohydrate salt is sold under brands such as Monodox and Adoxa, while the closely related hyclate salt is sold under names like Vibramycin, Doryx, and Acticlate. Keep in mind that some brand names appear in more than one salt form across the market, so the label is what tells you exactly which product and salt you have. A generic version is available.

How much does doxycycline monohydrate cost without insurance?

Because doxycycline monohydrate is a generic, it's generally an affordable antibiotic even if you're paying cash. That said, the price you actually pay can differ widely between pharmacies in the same town, so it's worth comparing before you fill. Rx.com compares cash prices across more than 60,000 pharmacies and shows you a coupon you can bring to the counter, no insurance and no membership required.

Prices change often and depend on your location, the strength, and the quantity, so we don't list a fixed dollar amount here. Enter your ZIP above to see today's price near you and pick the pharmacy with the best deal.

Alternatives and related antibiotics

Doxycycline comes in two closely related salt forms. Doxycycline monohydrate and doxycycline hyclate both deliver the same active antibiotic, doxycycline, and are used to treat the same infections; the main differences are in the specific products available and, for some people, how the stomach tolerates them. You can also compare the general doxycycline listing.

Other antibiotics your provider might consider, depending on the infection, include minocycline (another tetracycline), amoxicillin, azithromycin, and cephalexin. Which antibiotic is right for you depends on the type of infection and your medical history, so follow your provider's prescription. You can compare prices for any of these on Rx.com.

Safety and important precautions

This is general information, not medical advice, so always follow your prescriber's and pharmacist's instructions. A few important points: doxycycline should not be used during pregnancy or in children under 8 years old, because it can cause permanent tooth discoloration and slow bone growth. It commonly increases sensitivity to sunlight and can cause severe sunburn, so limit sun and UV exposure while taking it. To avoid throat and esophagus irritation, take each dose with a full glass of water and stay upright afterward, and don't take it right before bed.

Doxycycline can also cause diarrhea related to C. difficile that may appear even weeks after you finish, and rarely can cause increased pressure around the brain (pseudotumor cerebri) or serious allergic reactions. It may make hormonal birth control less effective. Antacids, calcium, iron, magnesium, and dairy can block its absorption, so separate those from your dose. Contact your provider if you have severe or lasting side effects.

Sources & accuracy

This Doxycycline Monohydrate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Doxycycline Monohydrate on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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