¿Qué es Methotrexate (Anti-Rheumatic)?

El metotrexato es un fármaco antirreumático modificador de la enfermedad (DMARD, por sus siglas en inglés) que se utiliza comúnmente para tratar la artritis reumatoide reduciendo la inflamación y ralentizando la progresión de la enfermedad. Funciona inhibiendo la enzima dihidrofolato reductasa, obstaculizando así las vías del folato que son críticas para la síntesis de ADN y la replicación celular. El metotrexato también se emplea en dosis más bajas para manejar otras condiciones autoinmunes y en dosis más altas para el tratamiento de ciertos tipos de cáncer.

Side Effects

• Change in how much or how often you urinate, lower back or side pain
• Fever, chills, cough, sore throat, body aches
• Chest pain, trouble breathing, blue lips or fingers

Warnings

• Keep all medicine out of the reach of children. Never share your medicine with anyone.
• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Female patients should use an effective form of birth control during treatment and for at least 3 or 6 months after the last dose. Male patients who have female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose.
• Do not breastfeed during treatment and for at least 1 week after the last dose.
• Tell your doctor if you have kidney disease, liver disease, blood or bone marrow problems (including anemia), diabetes, a weak immune system, any type of infection, stomach or bowel problem (including ulcers), lung or breathing problem, or a history of alcohol abuse.
• This medicine may cause the following problems:Serious infections, which may be life-threateningKidney problemsStomach or bowel problems, including ulcer or perforationLiver problemsLung or breathing problems, including acute or chronic interstitial pneumonitisSerious skin reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, or erythema multiformeIncreased risk of other cancers, including blood or skin cancerNerve problemsTumor lysis syndrome (electrolyte and metabolic problem that can be life-threatening)