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Nalbuphine Hcl Vial — prescription drug image

Nalbuphine Hcl

Nalbuphine HCl 10ML of 20MG/ML

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What is Nalbuphine Hcl?

Nalbuphine HCl is an opioid analgesic used for managing moderate to severe pain. It works by blocking pain signals in the brain. Common side effects include dizziness and nausea. Explore prescription options, savings, and connect with licensed providers at Rx.com.

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What is Nalbuphine Hcl ?

Nalbuphine HCl is an opioid analgesic used for managing moderate to severe pain. It works by blocking pain signals in the brain. Common side effects include dizziness and nausea. Explore prescription options, savings, and connect with licensed providers at Rx.com.
  • Severe confusion, lightheadedness, fainting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Blue lips, fingernails, or skin
  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
  • Severe constipation or stomach pain
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (such as asthma, bronchitis, COPD, sleep apnea), adrenal problems, gallbladder or pancreas problems, heart attack, slow heartbeat, or a history of brain tumor, head injury, depression, mental health problems, or seizures. Tell your doctor if you are addicted to drugs or alcohol.
  • This medicine may cause the following problems:High risk of overdose, which can lead to death Respiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome (when used with certain medicines)
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
Is nalbuphine a controlled substance?
Nalbuphine is not a federally scheduled controlled substance in the United States. It still carries opioid-class risks, including respiratory depression and the potential for abuse, misuse, and addiction, so it is used and monitored carefully by healthcare professionals.
What is nalbuphine (Nubain) used for?
Nalbuphine is FDA-approved to manage moderate to severe pain, to supplement balanced anesthesia before, during, and after surgery, and for pain relief during labor and delivery. It is given only by injection (IV, IM, or under the skin). Nubain was the original brand name but has been discontinued in the US, so only the generic is available.
How strong is nalbuphine compared to morphine?
Nalbuphine is considered roughly comparable to morphine in its pain-relieving strength on a milligram-for-milligram basis, but it works differently. As an agonist-antagonist, its pain relief and side effects level off at higher doses (a ceiling effect), and it generally has a lower potential for abuse than morphine. Your provider determines the right medicine and dose for your situation.
What are the side effects of nalbuphine?
Common side effects can include drowsiness, dizziness, nausea, and sweating. More serious risks include slowed or dangerous breathing, especially if combined with alcohol, benzodiazepines, or other CNS depressants. Because it is an opioid, it also carries a risk of abuse and dependence. Report any trouble breathing, severe drowsiness, or unusual symptoms to your care team right away.
Can nalbuphine cause opioid withdrawal?
Yes. In people who are physically dependent on other opioids (such as morphine or oxycodone), nalbuphine can precipitate opioid withdrawal because it blocks the mu-opioid receptor. For this reason it is not recommended in patients dependent on mu-opioids. Tell your provider about any current or recent opioid use before receiving nalbuphine.
How much does Nalbuphine Hcl cost without insurance?
The price of Nalbuphine Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 85% off retail prices with a free Rx.com coupon.
What are the common side effects of Nalbuphine Hcl?
Common side effects of Nalbuphine Hcl may include: Severe confusion, lightheadedness, fainting, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there, Blue lips, fingernails, or skin, Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Nalbuphine Hcl?
Generic versions may be available for Nalbuphine Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Nalbuphine Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Nalbuphine Hcl?
The cheapest pharmacy for Nalbuphine Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Nalbuphine Hcl near you.

Nalbuphine Hcl Coupons & Prices

Nalbuphine HCl 10ML of 20MG/ML

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Nalbuphine Hcl Vial — prescription drug image
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Nalbuphine Hcl prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
10ml of 20mg/ml · Vial 10 $101.69 $15.92
10ml of 10mg/ml · Vial 10 $42.99 $31.07

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a nalbuphine HCl coupon? Nalbuphine hydrochloride is a generic prescription pain medicine given only by injection, most often in hospitals, surgical, and labor-and-delivery settings. Because it is a generic given in clinical settings, the cash price can vary widely from one pharmacy or supplier to another, so comparing matters. Rx.com compares prices across more than 60,000 pharmacies so you can find a low cash price near you. Enter your ZIP above to see today's price on nalbuphine HCl.

What is nalbuphine HCl and how does it work?

Nalbuphine hydrochloride is an opioid pain reliever known as an agonist-antagonist analgesic. It activates one type of opioid receptor (the kappa receptor) to relieve pain while blocking another (the mu receptor). This unusual dual action means it can ease moderate to severe pain but tends to have a lower potential for abuse than pure opioids such as morphine. It was once sold under the brand name Nubain, which has been discontinued in the United States, so today it is available only as a generic.

Nalbuphine is given only by injection into a vein (IV), into a muscle (IM), or under the skin (subcutaneous). It is FDA-approved for the management of moderate to severe pain, as a supplement to balanced anesthesia before, during, and after surgery, and for pain relief during labor and delivery. Because it is administered by a healthcare professional, dosing and monitoring are handled by your medical team.

Cost of nalbuphine HCl without insurance

Nalbuphine is available only as a generic, and generics are generally far less expensive than brand-name drugs. Even so, cash prices for injectable medicines can differ a lot depending on the pharmacy or supplier, so it pays to compare before you fill. There is no manufacturer savings card for nalbuphine because the brand (Nubain) is discontinued in the US.

If you are paying without insurance, or if a cash coupon price beats your copay, an Rx.com discount can help. We compare prices across more than 60,000 pharmacies so you can see what nalbuphine HCl actually costs near you. Enter your ZIP above to see today's price and print or show your free coupon at the pharmacy.

Nalbuphine alternatives and related medicines

Nalbuphine belongs to a family of opioid agonist-antagonist and related pain medicines. If nalbuphine is not the right fit, your provider may consider other options. Related medicines include:

Each of these works a little differently and carries its own risks and benefits. Only your provider can decide which is appropriate for you, but you can compare cash prices on any of them here on Rx.com.

Safety and side effects to know

Nalbuphine carries the warnings common to opioid medicines. It can cause life-threatening slowed breathing (respiratory depression), and it has potential for abuse, misuse, and addiction, though generally lower than pure mu-opioids like morphine. Importantly, in people who are physically dependent on other opioids, nalbuphine can trigger opioid withdrawal, so it is not recommended for patients dependent on mu-opioids. Common side effects can include drowsiness, dizziness, nausea, and sweating.

Combining nalbuphine with alcohol, benzodiazepines, or other central-nervous-system depressants can dangerously increase sedation and breathing problems. Prolonged use during pregnancy can lead to neonatal opioid withdrawal syndrome in the newborn. This information is not medical advice. Always tell your provider about every medicine you take and any history of opioid use, and follow their guidance.

Sources & accuracy

This Nalbuphine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Nalbuphine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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