Paroxetine Hcl Er
Paroxetine hydrochloride extended-release
What is Paroxetine Hcl Er?
Paxil CR is an antidepressant used to treat depression, anxiety disorders, and certain other conditions. The generic version is Paroxetine ER. The average Paxil CR cash price is about $226 for a supply of 30, 20 mg Paxil CR controlled-release tablets. You can lower your Paxil cost by using our free Paxil CR coupon when you fill your prescription at a participating pharmacy near you.
Side Effects
- Confusion, weakness, muscle twitching
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, glaucoma, or a history of epilepsy or seizures.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsIncreased risk of broken bonesSexual problems
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
Prescription savings · · · ·
What is Paroxetine Hcl Er ?
Paxil CR is an antidepressant used to treat depression, anxiety disorders, and certain other conditions. The generic version is Paroxetine ER. The average Paxil CR cash price is about $226 for a supply of 30, 20 mg Paxil CR controlled-release tablets. You can lower your Paxil cost by using our free Paxil CR coupon when you fill your prescription at a participating pharmacy near you.
- Confusion, weakness, muscle twitching
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Bone pain, tenderness, swelling, or bruising
- Changes in behavior, thoughts of hurting yourself or others
- Eye pain, vision changes, seeing halos around lights
- Unusual bleeding or bruising
- Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
- Trouble keeping still, feeling restless and agitated, racing thoughts, excessive energy, trouble sleeping
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, glaucoma, or a history of epilepsy or seizures.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsIncreased risk of broken bonesSexual problems
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- This medicine may decrease the amount of sperm men make and affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Paroxetine Hcl Er Coupons & Prices
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Looking for a paroxetine HCl ER coupon? Paroxetine hydrochloride extended-release is the generic version of Paxil CR, and because it is available as a generic it is already one of the lower-cost SSRI antidepressants. Even so, the cash price can vary widely from one pharmacy to the next, so comparing before you fill really matters. Rx.com checks prices across more than 60,000 pharmacies so you can find today's lowest price near you with no insurance required. Enter your ZIP above to see today's price on paroxetine HCl ER.
What is paroxetine HCl ER and how does it work?
Paroxetine HCl ER (extended-release) is a selective serotonin reuptake inhibitor (SSRI) antidepressant, the same active ingredient found in the brand Paxil CR. SSRIs work by increasing the amount of serotonin, a natural chemical messenger, available in the brain, which can help improve mood and reduce anxiety over time. The extended-release formulation releases the medicine gradually through the day.
Paroxetine HCl ER is FDA-approved in adults to treat major depressive disorder (MDD), panic disorder, social anxiety disorder (social phobia), and premenstrual dysphoric disorder (PMDD). The extended-release tablets should be swallowed whole - do not chew or crush them. Always take it exactly as your provider prescribes.
How much does paroxetine HCl ER cost without insurance?
Because paroxetine HCl ER is available as a generic, it is generally far less expensive than the brand-name Paxil CR. That said, the cash price you pay can differ a lot depending on which pharmacy you use - even pharmacies on the same street can quote very different prices. That is exactly why comparing pays off.
Rx.com compares paroxetine HCl ER prices across more than 60,000 pharmacies and shows a coupon you can use at the counter, with no insurance needed. Prices change often and are shown live on this page, so enter your ZIP above to see today's price near you.
Paroxetine HCl ER alternatives and related medicines
Paroxetine comes in more than one form, and there are several other SSRI and SNRI antidepressants your provider might consider. Related options include:
- Paroxetine (immediate-release generic) and its brand Paxil
- Paxil CR, the brand-name extended-release equivalent of paroxetine HCl ER
- Other SSRIs such as sertraline, escitalopram, and fluoxetine
- The SNRI venlafaxine
These medicines differ in dosing, side effects, and how they are taken. Only your prescriber can decide which is right for you - this list is for comparison, not a recommendation to switch.
Important safety information
Paroxetine HCl ER carries a boxed warning that antidepressants can increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults; it is not approved for use in children. Do not take it with, or within 14 days of, an MAO inhibitor, and avoid it with thioridazine or pimozide. Tell your provider about all medicines you take, since combining it with other serotonergic drugs raises the risk of serotonin syndrome, and taking it with NSAIDs, aspirin, or warfarin can increase bleeding risk. Other possible effects include low sodium (hyponatremia/SIADH), activation of mania, and angle-closure glaucoma.
Do not stop paroxetine HCl ER suddenly - stopping abruptly can cause discontinuation symptoms, so your provider will usually taper the dose. Paroxetine is generally avoided in pregnancy because first-trimester exposure has been linked to cardiovascular malformations; tell your provider if you are or may become pregnant. This information is not medical advice - talk with your doctor or pharmacist about your specific situation before starting or changing this medicine.
This Paroxetine Hcl Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Paroxetine Hcl Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.