Tacrolimus
Tacrolimus 30GM of 0.1%
What is Tacrolimus?
Tacrolimus is a generic medication used to prevent the rejection of a kidney, heart or liver transplant. The average price of Tacrolimus is around $103 for a supply of 100, 0.5 mg capsules. Use our Rx.com savings offer to get great discounts on Tacrolimus at participating pharmacies near you.Side Effects
- Fever, chills, cough, stuffy or runny nose, sore throat, body aches
- Rapid weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, or weakness
Warnings
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may cause the following problems:Increased risk of serious infectionsIncreased risk of cancer (including skin cancer, lymphoma)DiabetesHigh blood pressure, changes in heart rhythm (including QT prolongation, torsade de pointes), heart problemsBrain or nerve problems (including posterior reversible encephalopathy syndrome, seizures)Kidney problemsThrombotic microangiopathy (damage in the smallest blood vessels), hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, heart rhythm problems, high blood pressure, cystic fibrosis, or any type of infection. Tell your doctor if you are African-American or have African or Hispanic ancestry.
- This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
Prescription savings · · · ·
What is Tacrolimus ?
Tacrolimus is a generic medication used to prevent the rejection of a kidney, heart or liver transplant. The average price of Tacrolimus is around $103 for a supply of 100, 0.5 mg capsules. Use our Rx.com savings offer to get great discounts on Tacrolimus at participating pharmacies near you.- Fever, chills, cough, stuffy or runny nose, sore throat, body aches
- Rapid weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, or weakness
- Swollen glands in your armpits or groin
- Increased thirst or hunger
- Fast, slow, or pounding heartbeat
- Dizziness, lightheadedness, or fainting
- Headache, vision changes, tremors, seizures, tingling or numbness
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, painful urination, bloody urine
- Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or lips
- Skin changes or growths
- Weakness on one side of your body, confusion, clumsiness, trouble thinking clearly
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may cause the following problems:Increased risk of serious infectionsIncreased risk of cancer (including skin cancer, lymphoma)DiabetesHigh blood pressure, changes in heart rhythm (including QT prolongation, torsade de pointes), heart problemsBrain or nerve problems (including posterior reversible encephalopathy syndrome, seizures)Kidney problemsThrombotic microangiopathy (damage in the smallest blood vessels), hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, heart rhythm problems, high blood pressure, cystic fibrosis, or any type of infection. Tell your doctor if you are African-American or have African or Hispanic ancestry.
- This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Rapid weight gain, swelling in your hands, ankles, or feet
- Skin changes or growths
- Swollen glands in your armpits or groin
- Unusual bleeding, bruising, or weakness
- Weakness on one side, confusion, clumsiness, trouble thinking clearly
Tacrolimus Coupons & Prices
Tacrolimus 30GM of 0.1%
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Looking for a tacrolimus coupon? Tacrolimus is the low-cost generic version of Prograf, a calcineurin inhibitor immunosuppressant used to help prevent organ rejection after a kidney, liver, heart, or lung transplant. Because it is a generic, tacrolimus is already far more affordable than the brand, but cash prices can still vary widely from one pharmacy to the next. Rx.com compares tacrolimus prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see today's price on tacrolimus and print or text yourself a free coupon.
What is tacrolimus and how does it work?
Tacrolimus is a calcineurin inhibitor immunosuppressant. It works by quieting part of the immune system so the body is less likely to attack and reject a transplanted organ. Immediate-release capsules and the injectable form (sold under the brand Prograf) are approved to help prevent rejection in kidney, liver, heart, and lung transplant patients, and are used together with other immunosuppressant medicines. Extended-release forms, Astagraf XL and Envarsus XR, are approved for kidney transplant.
There is also a topical tacrolimus ointment (Protopic) approved to treat atopic dermatitis (eczema). Tacrolimus is sometimes used off-label for other immune-related conditions, but you should only take it for the reason your prescriber has recommended. This information is educational and not a substitute for your doctor's or pharmacist's advice.
Tacrolimus cost and coupons without insurance
Tacrolimus is available as a generic, which is the biggest reason it costs much less than brand-name Prograf. Even so, the cash price you pay can differ a lot depending on which pharmacy you use, your strength and quantity, and where you live. That is exactly why comparing matters. Rx.com checks tacrolimus prices at more than 60,000 pharmacies and shows you the lowest available price, along with a free coupon you can use with or without insurance. Enter your ZIP above to see today's price.
Prograf's maker also offers a manufacturer savings program for eligible, commercially insured patients. You can review the current terms on the official page at prograf.com/savings-information; eligibility and terms vary and are set by the manufacturer, not by Rx.com.
Tacrolimus alternatives and related medicines
Transplant patients are almost always on a combination of medicines, and your care team chooses the mix that is right for you. Other immunosuppressants that are sometimes used alongside or instead of tacrolimus include cyclosporine (another calcineurin inhibitor), mycophenolate, sirolimus, everolimus, and the corticosteroid prednisone.
If you were prescribed brand-name Prograf, ask your pharmacist whether generic tacrolimus is appropriate for you, since it can lower your cost. Do not switch between tacrolimus products or brands on your own. The different forms are not interchangeable and any change should be managed by your prescriber.
Tacrolimus safety and important warnings
Tacrolimus carries a boxed warning: like other immunosuppressants, it increases the risk of serious infections and of certain cancers, including lymphoma and skin cancers. It should be prescribed and managed by physicians experienced in immunosuppressive therapy and transplant care. The extended-release form Astagraf XL carries an additional boxed warning of increased death in female liver transplant patients and is not approved for liver transplant.
Tacrolimus has a narrow therapeutic index, which means blood levels must be monitored and doses adjusted carefully. Possible risks include kidney problems (nephrotoxicity), nervous-system effects such as tremor, headache, or seizures, new diabetes after transplant, high potassium, high blood pressure, and QT prolongation. It also interacts with many drugs and foods that affect the CYP3A enzyme, so avoid grapefruit and grapefruit juice. Always tell your provider about every medicine and supplement you take, and follow their monitoring schedule. This is general information, not medical advice; talk with your provider about your specific situation.
This Tacrolimus information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Tacrolimus on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.