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Tizanidine Hcl

tiZANidine HCl 4MG

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What is Tizanidine Hcl?

Zanaflex is used to treat muscle spasticity. The generic version is tizanidine. The average Zanaflex cash price for a supply of 150, 4 mg oral capsules is $303. You can save up to 80% of the Zanaflex retail price by using our free coupon at participating pharmacies near you that participate with Rx.com.

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What is Tizanidine Hcl ?

Zanaflex is used to treat muscle spasticity. The generic version is tizanidine. The average Zanaflex cash price for a supply of 150, 4 mg oral capsules is $303. You can save up to 80% of the Zanaflex retail price by using our free coupon at participating pharmacies near you that participate with Rx.com.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Lightheadedness, dizziness, or fainting
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Seeing or hearing things that are not really there
  • Slow heartbeat
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.
  • This medicine may cause the following problems:Low blood pressureLiver damage
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you are dizzy.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
Is tizanidine a narcotic or controlled substance?
No. Tizanidine is not a narcotic and is not a federally controlled substance. It is a prescription skeletal muscle relaxant that works on the nervous system, but it does not carry a DEA controlled-substance schedule.
How is tizanidine different from cyclobenzaprine (Flexeril)?
Both are muscle relaxants, but they work differently and feel different. Tizanidine is an alpha-2 adrenergic agonist that is short-acting and can lower blood pressure and cause drowsiness. Cyclobenzaprine is chemically related to tricyclic antidepressants and is typically dosed for short-term relief of muscle spasm from acute pain. Your prescriber chooses between them based on your condition, other medicines, and how you tolerate side effects.
How long does tizanidine take to work and how long does it last?
Tizanidine is short-acting. Its effect comes on relatively quickly and then wears off within a few hours, which is why it is often taken only for the times when relief of muscle tightness matters most. Because food can change how it is absorbed, take it the same way each time as directed. Follow your prescriber's dosing schedule for your specific situation.
Can you take tizanidine and ibuprofen together?
There is no known direct interaction between tizanidine and ibuprofen, and they are sometimes used together for pain and muscle spasm. Still, confirm with your pharmacist or doctor first, since your overall health, kidney function, and other medications matter. Do not combine tizanidine with alcohol, opioids, or other sedatives without medical guidance, because that increases drowsiness and lowered blood pressure.
What should you avoid while taking tizanidine?
Avoid alcohol and other sedating substances, which add to tizanidine's drowsiness. Avoid driving or operating machinery until you know how it affects you. Do not take it with the antibiotic ciprofloxacin or the antidepressant fluvoxamine, as these are contraindicated and can cause dangerously low blood pressure. Do not stop high or long-term doses suddenly, and tell your provider about kidney or liver problems before starting.
How much does Tizanidine Hcl cost without insurance?
The price of Tizanidine Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Tizanidine Hcl?
Common side effects of Tizanidine Hcl may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Lightheadedness, dizziness, or fainting, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Seeing or hearing things that are not really there, Slow heartbeat. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Tizanidine Hcl?
Generic versions may be available for Tizanidine Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Tizanidine Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Tizanidine Hcl?
The cheapest pharmacy for Tizanidine Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Tizanidine Hcl near you.

Tizanidine Hcl Coupons & Prices

tiZANidine HCl 4MG

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Tizanidine Hcl Tablet — prescription drug image
Prescription
Tizanidine Hcl 4mg (20)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a tizanidine (Zanaflex) coupon? Tizanidine is a low-cost generic skeletal muscle relaxant, but the cash price can still vary a lot from one pharmacy to the next, so comparing before you fill is what saves you money. Rx.com checks tizanidine prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use with or without insurance. Enter your ZIP above to see today's price near you.

What is tizanidine and how does it work?

Tizanidine is a centrally acting alpha-2 adrenergic agonist, a type of skeletal muscle relaxant. It works in the brain and spinal cord to reduce nerve signals that cause muscles to tighten, easing muscle spasm, cramping, and tightness. It is the generic form of the brand Zanaflex.

Tizanidine is FDA-approved for the management of spasticity, such as the muscle tightness caused by multiple sclerosis or spinal cord injury. Because its effect is short-acting, doctors often reserve it for the activities and times of day when relief of spasticity matters most. It comes as both tablets and capsules; note that the two are not always bioequivalent because food changes how the drug is absorbed, so follow your prescriber's directions about taking it consistently with or without food.

How much does tizanidine cost, and how can a coupon help?

Tizanidine is available as an FDA-approved generic, so it is already one of the more affordable muscle relaxants. Even so, the cash price without insurance is not the same everywhere. Independent and chain pharmacies set their own prices, and the difference between two stores in the same town can be significant. That is exactly why comparing pays off.

Rx.com compares tizanidine prices across more than 60,000 pharmacies and provides a free coupon that can lower your out-of-pocket cost, whether or not you use insurance. There is no manufacturer copay savings card for generic tizanidine. To see the current price and the coupon for the strength and quantity you were prescribed, enter your ZIP above.

Tizanidine vs. other muscle relaxants

Tizanidine is one of several muscle relaxants, and the right choice depends on your condition and how you tolerate side effects. It tends to be shorter-acting and can cause noticeable drowsiness and lowered blood pressure. Related options your prescriber might consider include:

  • Cyclobenzaprine (generic Flexeril) — commonly used for short-term muscle spasm from acute pain.
  • Baclofen — another option used for spasticity, including from MS or spinal cord injury.
  • Methocarbamol — used for muscle spasm relief.
  • Metaxalone — often chosen when a less-sedating option is preferred.

All of these are available as generics. Only your prescriber can decide which fits your situation, so use this as a starting point for a conversation, not medical advice.

Tizanidine safety and important warnings

Tizanidine has no boxed warning, but there are important cautions. It commonly causes marked sedation, low blood pressure, and slowed heart rate, especially when the dose is increased, so use care with driving until you know how it affects you. Do not exceed 36 mg per day (three doses), and your provider may monitor your liver function because tizanidine can affect the liver. Do not stop high or long-term doses abruptly, as this can cause rebound high blood pressure and rapid heart rate; your prescriber will taper you off.

Tizanidine is contraindicated with the strong CYP1A2 inhibitors fluvoxamine and ciprofloxacin, which can raise tizanidine levels sharply and cause dangerously low blood pressure. It can add to the sedating effects of alcohol, opioids, and other sedatives, and may cause dose-related QT prolongation or, rarely, hallucinations. Use extra caution in older adults and in people with kidney problems. This is a summary, not a complete list; always review your full medication list and health history with your doctor or pharmacist.

Sources & accuracy

This Tizanidine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Tizanidine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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