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Clonidine

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What is Clonidine?

If you suffer from attention deficit hyperactivity disorder, your doctor might prescribe clonidine. Physicians have also used clonidine to treat anxiety disorder, migraines, menopause symptoms (flushing), and pain disorders. Clonidine might cause sedation so caution should be used when first taking the drug.

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What is Clonidine ?

If you suffer from attention deficit hyperactivity disorder, your doctor might prescribe clonidine. Physicians have also used clonidine to treat anxiety disorder, migraines, menopause symptoms (flushing), and pain disorders. Clonidine might cause sedation so caution should be used when first taking the drug.
  • Unusual tiredness or weakness
  • Lightheadedness, dizziness, drowsiness, or fainting
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Skin rash, blistering, swelling, or redness where the patch is worn
  • Fast, slow, pounding, or uneven heartbeat
  • Unusual bleeding or bruising
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • This medicine contains aluminum. Before you have an MRI, remove the patch. Aluminum can cause skin burns at the patch site during an MRI.
  • This medicine may make you drowsy, dizzy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Even if you feel well, do not stop using the medicine without asking your doctor. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • This medicine may cause dry eye, especially if you wear contact lenses. Ask your doctor how to treat the dryness.
  • Tell your doctor if you are pregnant or breastfeeding or if you have kidney disease, heart or blood vessel disease, heart rhythm problems, or a history of heart attack or stroke.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
What is clonidine used for?
Clonidine is FDA-approved to treat high blood pressure, and two of its extended-release forms — Kapvay (ages 6 to 17) and Onyda XR (ages 6 and older) — are approved for ADHD in children. An epidural form (Duraclon) is approved for severe cancer pain. Your provider can explain why it was prescribed for you.
What are the most common side effects of clonidine?
The most common side effects are drowsiness or sedation, dizziness, dry mouth, and a drop in blood pressure when standing up. It can also slow the heart rate. Avoid driving until you know how it affects you, and tell your provider about any bothersome or lasting side effects.
Can you stop taking clonidine suddenly?
No. Stopping clonidine abruptly can cause rebound high blood pressure, a fast heartbeat, agitation, and headache. If you need to stop, your provider will usually lower the dose gradually over about 2 to 4 days. Do not stop on your own without medical guidance.
Is clonidine used for anxiety or sleep?
Clonidine is FDA-approved for high blood pressure and, in its extended-release forms, for ADHD in children. It is sometimes used off-label for other purposes, but those uses are decided case by case by a prescriber. Only your doctor can determine whether clonidine is appropriate for you.
Is clonidine a controlled substance?
No. Clonidine is not a controlled substance and is not on the DEA schedule. It is a prescription medicine, so you still need a prescription from your provider to fill it.
How much does Clonidine cost without insurance?
The price of Clonidine without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 91% off retail prices with a free Rx.com coupon.
What are the common side effects of Clonidine?
Common side effects of Clonidine may include: Unusual tiredness or weakness, Lightheadedness, dizziness, drowsiness, or fainting, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Skin rash, blistering, swelling, or redness where the patch is worn, Fast, slow, pounding, or uneven heartbeat. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Clonidine?
Generic versions may be available for Clonidine. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Clonidine on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Clonidine?
The cheapest pharmacy for Clonidine depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Clonidine near you.

Clonidine Coupons & Prices

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Looking for a clonidine coupon? Clonidine is a widely used generic medicine, so it is already one of the more affordable prescriptions at the pharmacy counter — but the cash price can still vary a lot from one pharmacy to the next, which is exactly why comparing matters. Rx.com checks prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see the current price on clonidine tablets or the extended-release forms, and bring the free Rx.com coupon to the pharmacy to pay the cash price shown.

What is clonidine and how does it work?

Clonidine (clonidine hydrochloride) is a centrally acting alpha-2 adrenergic agonist. It works in the brain to reduce the nerve signals that tighten blood vessels and speed the heart, which lowers blood pressure and calms overactivity in the nervous system. It is available as immediate-release oral tablets and the Catapres-TTS transdermal patch, and as extended-release forms (Kapvay, Nexiclon XR, Onyda XR) that are dosed differently.

Clonidine is FDA-approved to treat high blood pressure (hypertension), used alone or with other blood-pressure medicines; the immediate-release tablets, the Catapres-TTS patch, and the Nexiclon XR extended-release tablets are all approved for this use. Two other extended-release forms are FDA-approved for ADHD in children — Kapvay in ages 6 to 17 and Onyda XR in ages 6 and older — either on their own or added to a stimulant. An epidural formulation (Duraclon) is approved for severe cancer pain. You may see clonidine sold under brand names including Catapres, Catapres-TTS, Kapvay, Nexiclon XR, and Onyda XR.

Clonidine cost and coupon savings without insurance

Clonidine is available as a generic, which is why it is generally low-cost compared with brand-name medicines. Even so, the cash price is not the same everywhere — different pharmacies set different prices for the same tablet, and the immediate-release, patch, and extended-release forms are priced separately. That spread is the reason it pays to compare before you fill. Enter your ZIP above to see today's price at pharmacies near you, then show the free Rx.com coupon at checkout to pay that cash price. The coupon can be used with or without insurance and is often useful when a plan does not cover a particular form.

The maker of the Nexiclon XR brand offers a manufacturer patient savings card, which you can look up on the official Nexiclon website; card terms and eligibility vary and typically exclude government insurance. For most people filling generic clonidine, comparing the cash price with the Rx.com coupon is the simplest way to see what you would actually pay.

Clonidine alternatives and related medicines

Clonidine belongs to a broader group of blood-pressure and ADHD medicines, and the right choice depends on why it is being prescribed. A close relative is guanfacine, another alpha-2 agonist used for blood pressure and ADHD. Other blood-pressure options your provider might compare include methyldopa (also a centrally acting agent), lisinopril (an ACE inhibitor), and amlodipine (a calcium channel blocker). For ADHD, a non-stimulant alternative is atomoxetine.

These medicines work in different ways and are not interchangeable, so only your prescriber can decide which fits your situation. Where a generic is available, you can compare the cash price of each on Rx.com to help inform that conversation.

Clonidine safety and side effects

The most important thing to know about clonidine is not to stop it suddenly. Abruptly stopping — especially at higher doses — can cause rebound high blood pressure, a fast heartbeat, agitation, and headache. If you and your provider decide to stop, the dose is usually tapered down gradually over about 2 to 4 days. Common side effects include drowsiness or sedation, dizziness, dry mouth, and a drop in blood pressure when standing up (orthostatic hypotension), so avoid driving until you know how it affects you. Clonidine can also slow the heart rate, and combining it with alcohol or other sedating medicines increases drowsiness.

The oral tablets and patch do not carry a boxed warning; the separate epidural Duraclon formulation does carry one against use in obstetrical, post-partum, or perioperative pain. Overdose — including accidental ingestion by children — can cause serious slow heart rate, low blood pressure, and drowsiness, so keep it stored safely. This information is educational and not medical advice; talk with your doctor or pharmacist about your specific health situation and any other medicines you take.

Sources & accuracy

This Clonidine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Clonidine on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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