Fluticasone-Salmeterol
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What is Fluticasone-Salmeterol?
Fluticasone-Salmeterol (Advair Diskus, Advair HFA, Wixela Inhub) is a prescription inhaled medication used for the long-term treatment of asthma and chronic obstructive pulmonary disease (COPD). It combines an inhaled corticosteroid with a long-acting bronchodilator to reduce airway inflammation, improve breathing, and help prevent asthma attacks and COPD flare-ups.
Side Effects
- Headache
- Throat irritation
- Hoarseness or changes in the voice
Warnings
- Risk of asthma-related death
- Pneumonia in patients with COPD
- Paradoxical bronchospasm
- Immune system effects and a higher chance of infections
- Adrenal insufficiency
Prescription savings · · · ·
What is Fluticasone-Salmeterol ?
Fluticasone-Salmeterol (Advair Diskus, Advair HFA, Wixela Inhub) is a prescription inhaled medication used for the long-term treatment of asthma and chronic obstructive pulmonary disease (COPD). It combines an inhaled corticosteroid with a long-acting bronchodilator to reduce airway inflammation, improve breathing, and help prevent asthma attacks and COPD flare-ups.
- Headache
- Throat irritation
- Hoarseness or changes in the voice
- Oral thrush (candida infection)
- Upper respiratory tract infections
- Cough
- Musculoskeletal pain
- Risk of asthma-related death
- Pneumonia in patients with COPD
- Paradoxical bronchospasm
- Immune system effects and a higher chance of infections
- Adrenal insufficiency
- Bone thinning or weakness (osteoporosis)
- Eye problems (including glaucoma and cataracts)
Fluticasone-Salmeterol Coupons & Prices
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Looking for a fluticasone-salmeterol coupon? Fluticasone propionate / salmeterol is the generic version of Advair Diskus, a daily maintenance (controller) combination inhaler used for asthma and COPD. Because a substitutable generic is available, it is often already much lower in cost than the brand, but the cash price can still vary widely from one pharmacy to another. Rx.com compares fluticasone-salmeterol prices across thousands of U.S. pharmacies, so you can enter your ZIP above to see today's price and print a free discount coupon that works whether or not you have insurance.
What is fluticasone-salmeterol and how does it work?
Fluticasone-salmeterol is a combination inhaler that pairs two medicines: fluticasone propionate, an inhaled corticosteroid (ICS) that reduces inflammation in the airways, and salmeterol, a long-acting beta2-agonist (LABA) that relaxes and opens the airway muscles for many hours. Together they help keep the airways open and calm over time. The best-known brand is Advair Diskus (also sold as Advair HFA), and Wixela Inhub is the FDA-approved substitutable generic of Advair Diskus. A separate product, AirDuo RespiClick/Digihaler, contains the same two drugs but uses a different inhaler device and a lower salmeterol dose; it is approved for asthma only (ages 12 and older) and is not interchangeable with Advair.
Fluticasone-salmeterol is FDA-approved as a preventive, maintenance (controller) inhaler, not a rescue inhaler. Advair Diskus is used for asthma in patients whose disease is not adequately controlled on an inhaled corticosteroid alone, and for the maintenance treatment of airflow obstruction and reducing flare-ups in COPD (chronic bronchitis and/or emphysema). Different products and strengths are approved for asthma versus COPD - for example, AirDuo is approved for asthma only - so your provider will match the right one to your condition. It does not relieve a sudden asthma attack.
Fluticasone-salmeterol cost and how to save without insurance
Because a substitutable generic of Advair Diskus (Wixela Inhub) is available, fluticasone-salmeterol is generally already less expensive than the brand-name Advair. Even so, the cash price is not the same everywhere. The same inhaler can cost noticeably more at one pharmacy than another nearby, which is exactly why comparing prices matters. Rx.com checks prices at thousands of pharmacies so you can find the lower option in your area. Enter your ZIP above to see today's price and get a free coupon you can use at the pharmacy counter.
If you are prescribed a brand-name version, the manufacturer may also offer a savings and support program. To check current eligibility and terms, search for the Advair savings card on the manufacturer's official website; manufacturer cards typically do not apply if you use government insurance such as Medicare or Medicaid. For most people the generic plus a discount coupon is the simplest way to keep costs down.
Alternatives and related inhalers to compare
Fluticasone-salmeterol is one of several ICS/LABA combination inhalers. Another common combination is budesonide-formoterol (brand Symbicort), and Breo Ellipta is a once-daily combination option. Your provider chooses among these based on your condition, dosing preference, and how well your breathing is controlled.
It can also help to understand the individual pieces and other approaches. Fluticasone-salmeterol combines the steroid fluticasone with the long-acting bronchodilator salmeterol. Some people also use a daily tablet such as montelukast, and a separate quick-relief rescue inhaler such as albuterol for sudden symptoms. Prices for all of these are searchable on Rx.com, so you can compare before you fill.
Safety and important warnings
Long-acting beta2-agonists (LABAs) carry a class warning: when used alone for asthma, they can increase the risk of asthma-related death. Using a fixed-dose ICS/LABA combination like fluticasone-salmeterol lowers that risk, and once asthma is well controlled your provider may step you down to an inhaled steroid alone when appropriate. This inhaler is not for relief of a sudden, severe asthma attack or acute bronchospasm, so keep a rescue inhaler on hand.
Possible side effects include oral thrush (a yeast infection in the mouth) - rinsing your mouth with water after each dose helps prevent it - as well as paradoxical bronchospasm, a higher chance of pneumonia in people with COPD, and, with corticosteroids, effects such as adrenal suppression, reduced bone density, and glaucoma or cataracts. It can also raise heart rate and blood pressure and lower potassium. Avoid combining it with strong CYP3A4 inhibitor medicines. This is general information, not medical advice; talk with your doctor or pharmacist about what is right for you and never stop or change your inhaler without their guidance.
This Fluticasone-Salmeterol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Fluticasone-Salmeterol on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.