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Altreno

Altreno 20GM of 0.05%

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What is Altreno?

Altreno is a topical medication used to treat acne and reduce fine wrinkles. It helps improve skin by promoting the growth of new skin cells and unclogging pores.

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What is Altreno ?

Altreno is a topical medication used to treat acne and reduce fine wrinkles. It helps improve skin by promoting the growth of new skin cells and unclogging pores.

Source: MedlinePlus, U.S. National Library of Medicine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe or ongoing skin redness, peeling, itching, blistering, crusting, or swelling
  • Skin warmth, stinging, or burning that continues or gets worse
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. During the first 3 to 6 weeks of using this medicine, your acne may seem to get worse. This means the medicine is working, and it is important that you keep using it.
  • This medicine may make your skin more sensitive to sunlight, wind, and cold weather. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. You may need to wear protective clothing, including long sleeves and a hat.
  • The gel form of this medicine is flammable. Do not smoke while you are using this medicine. Always keep it away from fire, flames, or high heat.
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have a fish allergy, eczema, sunburn, or other skin problems.
What is Altreno used for?
Altreno is a prescription tretinoin lotion (0.05%) approved to treat acne vulgaris in people 9 years of age and older. You apply a thin layer to the affected skin once a day. It is for use on the skin only, not for the eyes, mouth, or internal use.
Is Altreno the same as regular tretinoin (Retin-A)?
Altreno contains the same active ingredient as tretinoin products like Retin-A, but it is a newer, water-based lotion formulation designed to be gentler and easier to apply. Retin-A and generic tretinoin typically come as creams and gels. Because Altreno is brand-only with no generic, it is often more expensive than traditional tretinoin.
Is there a generic version of Altreno?
No. There is currently no generic version of Altreno. It is available only as the brand product. If cost is a concern, ask your prescriber whether a generic tretinoin cream or gel, or another retinoid, might be an option for you.
How long does Altreno take to work for acne?
Results vary from person to person, and topical retinoids often take several weeks of consistent daily use before you notice improvement. Some irritation is common early on. Keep using it as directed and follow up with your prescriber - this page is general information, not medical advice.
How much does Altreno cost, and is there a savings card?
Prices change and are shown live on this page - enter your ZIP above to see today's cash price at pharmacies near you. Ortho Dermatologics offers a manufacturer copay savings card, but it is generally limited to patients with commercial insurance; check altreno.com/get-altreno for current terms. If you are uninsured, on Medicare, or the card is declined, a free Rx.com cash coupon may help you save.
How much does Altreno cost without insurance?
The price of Altreno without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Altreno?
Common side effects of Altreno may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Severe or ongoing skin redness, peeling, itching, blistering, crusting, or swelling, Skin warmth, stinging, or burning that continues or gets worse. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Altreno?
Generic versions may be available for Altreno. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Altreno on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Altreno?
The cheapest pharmacy for Altreno depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Altreno near you.

Altreno Coupons & Prices

Altreno 20GM of 0.05%

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Altreno Tube Of Lotion — prescription drug image
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Looking for an Altreno coupon? Altreno (tretinoin topical lotion 0.05%) is a once-daily, water-based prescription retinoid used to treat acne in people 9 years and older. Because there is no generic version yet, Altreno can be costly at the pharmacy. On this page you can compare cash prices at pharmacies near you and use a free Rx.com discount coupon that may lower the cost when you do not have insurance, are on Medicare, or when a manufacturer card is declined. Enter your ZIP above to see today's price.

What is Altreno and how does it work?

Altreno is a brand-name prescription form of tretinoin, a topical retinoid (a vitamin A derivative). It is FDA-approved to treat acne vulgaris in patients 9 years of age and older. What sets Altreno apart from older tretinoin creams and gels is its water-based lotion formulation, which is designed to be gentler and easier to spread. You apply a thin layer to the affected areas of skin once a day.

Altreno is for use on the skin only. It is not meant for the eyes, mouth, or for oral, vaginal, or ophthalmic use. Tretinoin as an ingredient is sometimes used off-label for photoaging or dark spots, but Altreno itself is approved only for acne. Always follow your prescriber's directions.

Altreno cost, manufacturer savings card, and the Rx.com cash coupon

Altreno is a brand-only product with no generic available, so it is often one of the pricier acne treatments. There are two main ways to save, and they work in different situations:

  • Manufacturer savings card: Ortho Dermatologics offers a copay savings program for Altreno. These cards are generally for patients with commercial (private) insurance and typically exclude government coverage like Medicare or Medicaid. Terms, eligibility, and any dollar limits vary and change over time, so check the official page at altreno.com/get-altreno.
  • Rx.com cash coupon: Our free discount coupon is a cash-price option, so it can help when you are uninsured, on Medicare, or when the manufacturer card is declined or you do not qualify for it. It is not insurance. Enter your ZIP above to see today's price at pharmacies near you and print or show your coupon.

Prices change often and are shown live on this page, so compare both options and use whichever is lower for you.

Altreno vs. other tretinoin and acne retinoids

Altreno is one of several topical retinoids used for acne. If cost is a concern, it is worth talking with your prescriber about alternatives, since some come in generic forms:

  • Tretinoin and Retin-A - the same active ingredient as Altreno, in traditional cream and gel formulations.
  • Differin (adapalene) - a different retinoid available over the counter and by prescription.
  • Tazorac (tazarotene) - another prescription topical retinoid.
  • Epiduo - a combination gel of adapalene and benzoyl peroxide.

These products differ in strength, formulation, and how they are tolerated. This is general information, not medical advice - your dermatologist or prescriber can help you choose the right option for your skin.

Altreno safety and side effects

Altreno has no boxed warning. The most common effects, especially early in treatment, are skin irritation - redness, scaling, dryness, and stinging, burning, or itching where you apply it. Altreno can also make your skin more sensitive to sunlight, so avoid excessive sun and UV exposure, use sunscreen and protective clothing, and use extra caution on sunburned or eczema-prone skin. Avoid getting it in your eyes, mouth, the creases around your nose, and other mucous membranes, and try to avoid weather extremes like wind and cold.

Altreno's safety in pregnancy has not been established; oral retinoids are known to cause birth defects, so it should be used only if clearly needed and after talking with your provider. Because Altreno contains a fish-derived collagen ingredient, people with fish allergies may be at risk of an allergic reaction. Using other medicated, abrasive, or drying skin products at the same time can increase irritation. This is not medical advice - tell your provider about your full health history and any other products you use, and read the medication guide that comes with your prescription.

Sources & accuracy

This Altreno information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Altreno on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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