Divalproex Sodium Er
Divalproex Sodium ER 500MG
What is Divalproex Sodium Er?
Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Sudden and severe stomach pain, nausea, vomiting, lightheadedness
- Fever, rash, swollen glands in the neck, armpit, or groin
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, a viral infection (including HIV or cytomegalovirus infection), or a history of depression or mental health problems.
- This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Depression or thoughts of suicideBleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
Prescription savings · · · ·
What is Divalproex Sodium Er ?
Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.- Sudden and severe stomach pain, nausea, vomiting, lightheadedness
- Fever, rash, swollen glands in the neck, armpit, or groin
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Confusion, problems with memory, unusual drowsiness, clumsiness
- Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
- Unusual bleeding, bruising, or weakness
- Thoughts of hurting yourself, depression, unusual changes in behavior or moods
- Tiny red dots on the skin, especially on the lower legs
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, a viral infection (including HIV or cytomegalovirus infection), or a history of depression or mental health problems.
- This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Depression or thoughts of suicideBleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Divalproex Sodium Er Coupons & Prices
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Looking for a divalproex sodium ER coupon? Divalproex sodium extended-release (the generic form of Depakote ER) is a once-daily valproate medicine used for bipolar I manic episodes, certain seizure types, and migraine prevention. Because it is available as a widely stocked generic, the cash price is usually modest, but what you pay can vary a lot from one pharmacy to the next. Enter your ZIP above to compare the current price at pharmacies near you and get a free Rx.com discount you can use at the register even if you do not have insurance.
What is divalproex sodium ER and how does it work?
Divalproex sodium is an anticonvulsant and mood stabilizer in the valproate family. In the body it delivers valproic acid, which is thought to work mainly by increasing levels of a calming brain chemical called GABA and by steadying overactive electrical signaling in the brain. The extended-release (ER) tablet releases the medicine slowly so it can be taken once a day.
The FDA has approved divalproex sodium ER for three uses: treating manic episodes of bipolar I disorder; treating complex partial seizures and simple or complex absence seizures (alone or with other drugs) in patients 10 years and older; and preventing migraine headaches in adults. It is used to help stop migraines before they start, not to relieve a migraine that has already begun.
What does divalproex sodium ER cost without insurance?
Divalproex sodium ER is a mature generic, so it is generally one of the lower-cost options in its class. There is no manufacturer copay or savings card for the generic, and the brand maker (AbbVie, at the official Depakote website) does not offer a card for the generic version. That does not mean everyone pays the same, though. Cash prices swing widely by pharmacy, dose, and location, so the same prescription can cost meaningfully more at one store than another down the street.
That is where comparing pays off. Rx.com checks prices across more than 60,000 pharmacies and shows a free discount you can present at the counter, with or without insurance. Enter your ZIP above to see today's price near you before you fill.
Alternatives and related medications
Divalproex sodium ER is the once-daily version of Depakote ER. Closely related valproate products include divalproex sodium delayed-release, its brand Depakote, and valproic acid. These forms are not interchangeable milligram-for-milligram, so any switch should be guided by your prescriber.
For seizures and mood stabilization, providers sometimes consider other anticonvulsants such as lamotrigine or topiramate, which is also used for migraine prevention. Which medicine is right depends on your diagnosis, other health conditions, and pregnancy status. Compare prices on any of these with the ZIP tool above.
Safety and important warnings
Divalproex sodium ER carries three FDA boxed warnings, the agency's strongest safety alert. First, it can cause serious and sometimes fatal liver damage, with the highest risk in children under 2 and during the first 6 months of treatment; it should not be used by people with liver disease or certain mitochondrial disorders. Second, it can cause serious birth defects (including neural tube defects such as spina bifida), lower IQ, and neurodevelopmental problems in a baby if taken during pregnancy; it is not to be used for migraine prevention in pregnancy or in women who could become pregnant and are not using effective birth control. Third, it can cause pancreatitis, which can be severe.
Other risks include high blood ammonia levels affecting the brain, low platelet counts, a serious drug-reaction syndrome called DRESS, and, like other antiseizure drugs, a small increase in suicidal thoughts or behavior. Doctors typically check liver function and platelets before and during treatment. This is general information, not medical advice; talk with your doctor or pharmacist about your full medical history and any other medicines you take.
This Divalproex Sodium Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Divalproex Sodium Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.