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Divalproex Sodium Er Tablet — prescription drug image

Divalproex Sodium Er

Divalproex Sodium ER 500MG

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What is Divalproex Sodium Er?

Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.

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What is Divalproex Sodium Er ?

Depakote ER is used to help treat convulsions. The generic version of Depakote ER is Divalproex Sodium. On average Depakote ER is priced at about $446 for a supply of 60, 500 mg tablets, extended-release. You can use our Rx.com savings offer to get an average Depakote ER discount of up to 80% off of the retail price at participating pharmacies near you.
  • Sudden and severe stomach pain, nausea, vomiting, lightheadedness
  • Fever, rash, swollen glands in the neck, armpit, or groin
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Confusion, problems with memory, unusual drowsiness, clumsiness
  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
  • Unusual bleeding, bruising, or weakness
  • Thoughts of hurting yourself, depression, unusual changes in behavior or moods
  • Tiny red dots on the skin, especially on the lower legs
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, blood disease, pancreas problems, a viral infection (including HIV or cytomegalovirus infection), or a history of depression or mental health problems.
  • This medicine may cause the following problems:Liver problemsPancreatitis (swelling of the pancreas)Hyperammonemic encephalopathy (too much ammonia in your blood)Depression or thoughts of suicideBleeding problems (including thrombocytopenia)Hypothermia (low body temperature)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage the organs, including the liver, kidney, or heart
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is divalproex sodium ER used for?
Divalproex sodium extended-release is FDA-approved for three uses: treating manic episodes of bipolar I disorder; treating complex partial seizures and simple or complex absence seizures (alone or with other medicines) in people 10 years and older; and preventing migraine headaches in adults. It is used to prevent migraines, not to relieve one that has already started.
What is the difference between divalproex sodium ER and DR (delayed-release)?
ER stands for extended-release and is usually taken once a day, while DR stands for delayed-release and is often taken two or more times a day. The two forms are not equal milligram-for-milligram; the body absorbs slightly less from the ER tablet, so a dose change is usually needed when switching between them. Never switch forms on your own without your prescriber adjusting the dose.
Is divalproex sodium the same as Depakote?
Divalproex sodium is the generic name, and Depakote is a brand name for it. Divalproex sodium ER is the generic equivalent of Depakote ER, and divalproex sodium delayed-release is the generic equivalent of Depakote. They contain the same active ingredient and are considered substitutable by form.
What are the most serious side effects and warnings of divalproex sodium ER?
It has three FDA boxed warnings: severe, potentially fatal liver damage (highest risk in young children and early in treatment); serious harm to a developing baby, including birth defects and lower IQ, if taken during pregnancy; and pancreatitis. Other serious concerns include high blood ammonia, low platelet counts, the DRESS drug reaction, and a small risk of suicidal thoughts. Your doctor will typically monitor liver function and platelets. Contact your provider right away about severe abdominal pain, yellowing skin, unusual bruising, or mood changes.
Can you drink alcohol while taking divalproex sodium ER?
It is best to avoid or strictly limit alcohol. Alcohol can add to the drowsiness and dizziness this medicine causes, and both alcohol and divalproex can stress the liver, which is already a boxed-warning concern. Talk with your doctor or pharmacist about whether any alcohol is safe for you.
How much does Divalproex Sodium Er cost without insurance?
The price of Divalproex Sodium Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Divalproex Sodium Er?
Common side effects of Divalproex Sodium Er may include: Sudden and severe stomach pain, nausea, vomiting, lightheadedness, Fever, rash, swollen glands in the neck, armpit, or groin, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash, Confusion, problems with memory, unusual drowsiness, clumsiness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Divalproex Sodium Er?
Generic versions may be available for Divalproex Sodium Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Divalproex Sodium Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Divalproex Sodium Er?
The cheapest pharmacy for Divalproex Sodium Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Divalproex Sodium Er near you.

Divalproex Sodium Er Coupons & Prices

Divalproex Sodium ER 500MG

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Divalproex Sodium Er Tablet — prescription drug image
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Divalproex Sodium Er 500mg (60)
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Looking for a divalproex sodium ER coupon? Divalproex sodium extended-release (the generic form of Depakote ER) is a once-daily valproate medicine used for bipolar I manic episodes, certain seizure types, and migraine prevention. Because it is available as a widely stocked generic, the cash price is usually modest, but what you pay can vary a lot from one pharmacy to the next. Enter your ZIP above to compare the current price at pharmacies near you and get a free Rx.com discount you can use at the register even if you do not have insurance.

What is divalproex sodium ER and how does it work?

Divalproex sodium is an anticonvulsant and mood stabilizer in the valproate family. In the body it delivers valproic acid, which is thought to work mainly by increasing levels of a calming brain chemical called GABA and by steadying overactive electrical signaling in the brain. The extended-release (ER) tablet releases the medicine slowly so it can be taken once a day.

The FDA has approved divalproex sodium ER for three uses: treating manic episodes of bipolar I disorder; treating complex partial seizures and simple or complex absence seizures (alone or with other drugs) in patients 10 years and older; and preventing migraine headaches in adults. It is used to help stop migraines before they start, not to relieve a migraine that has already begun.

What does divalproex sodium ER cost without insurance?

Divalproex sodium ER is a mature generic, so it is generally one of the lower-cost options in its class. There is no manufacturer copay or savings card for the generic, and the brand maker (AbbVie, at the official Depakote website) does not offer a card for the generic version. That does not mean everyone pays the same, though. Cash prices swing widely by pharmacy, dose, and location, so the same prescription can cost meaningfully more at one store than another down the street.

That is where comparing pays off. Rx.com checks prices across more than 60,000 pharmacies and shows a free discount you can present at the counter, with or without insurance. Enter your ZIP above to see today's price near you before you fill.

Alternatives and related medications

Divalproex sodium ER is the once-daily version of Depakote ER. Closely related valproate products include divalproex sodium delayed-release, its brand Depakote, and valproic acid. These forms are not interchangeable milligram-for-milligram, so any switch should be guided by your prescriber.

For seizures and mood stabilization, providers sometimes consider other anticonvulsants such as lamotrigine or topiramate, which is also used for migraine prevention. Which medicine is right depends on your diagnosis, other health conditions, and pregnancy status. Compare prices on any of these with the ZIP tool above.

Safety and important warnings

Divalproex sodium ER carries three FDA boxed warnings, the agency's strongest safety alert. First, it can cause serious and sometimes fatal liver damage, with the highest risk in children under 2 and during the first 6 months of treatment; it should not be used by people with liver disease or certain mitochondrial disorders. Second, it can cause serious birth defects (including neural tube defects such as spina bifida), lower IQ, and neurodevelopmental problems in a baby if taken during pregnancy; it is not to be used for migraine prevention in pregnancy or in women who could become pregnant and are not using effective birth control. Third, it can cause pancreatitis, which can be severe.

Other risks include high blood ammonia levels affecting the brain, low platelet counts, a serious drug-reaction syndrome called DRESS, and, like other antiseizure drugs, a small increase in suicidal thoughts or behavior. Doctors typically check liver function and platelets before and during treatment. This is general information, not medical advice; talk with your doctor or pharmacist about your full medical history and any other medicines you take.

Sources & accuracy

This Divalproex Sodium Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Divalproex Sodium Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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