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Imipramine Hcl Tablet — prescription drug image

Imipramine Hcl

Imipramine HCl 25MG

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What is Imipramine Hcl?

Tofranil is a prescription medication used to treat depression. Imipramine is the generic version of Tofranil. The average price of Tofranil is around $585 for a supply of 30, 10 mg tablets. Use our Rx.com savings offer to get great discounts on Tofranil at participating pharmacies near you.

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What is Imipramine Hcl ?

Tofranil is a prescription medication used to treat depression. Imipramine is the generic version of Tofranil. The average price of Tofranil is around $585 for a supply of 30, 10 mg tablets. Use our Rx.com savings offer to get great discounts on Tofranil at participating pharmacies near you.
  • Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Fever, sore throat, cough, chills
  • Eye pain, vision changes, seeing halos around lights
  • Thoughts of hurting yourself or others, trouble sleeping, unusual behavior
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Agitation, irritability, sudden increase in energy, trouble sleeping
  • Fast, pounding, or uneven heartbeat
  • This medicine may raise or lower your blood sugar level.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney or liver disease, glaucoma, heart or blood vessel disease, heart rhythm problems, trouble urinating, thyroid problems, or a history of schizophrenia or seizures.
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may cause a serious reaction called serotonin syndrome, which can be life-threatening.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is imipramine used for?
Imipramine is a tricyclic antidepressant approved to relieve symptoms of depression, and as short-term add-on therapy for nighttime bedwetting (nocturnal enuresis) in children 6 years and older. It is sometimes used off-label for other conditions, but you should only use it for the reason your own doctor prescribes it.
How long does imipramine take to work?
Imipramine usually needs to be taken every day for a number of weeks before its full effect on mood is seen, though some people notice changes in sleep or energy sooner. Keep taking it as prescribed even if you do not feel better right away, and do not stop without talking to your doctor.
What are the most common side effects of imipramine?
The most common side effects are anticholinergic effects such as dry mouth, constipation, trouble urinating, and blurred vision, along with drowsiness and dizziness when standing up. Ask your doctor or pharmacist about any side effect that bothers you or does not go away.
Is imipramine a controlled substance?
No. Imipramine is not a controlled substance and has no DEA schedule. It is a prescription medicine, so you still need a valid prescription from your provider to fill it.
Can imipramine be used for anxiety or bedwetting?
Imipramine is FDA-approved as short-term add-on therapy for bedwetting (nocturnal enuresis) in children 6 and older. It is sometimes used off-label for anxiety-related conditions, but that is a decision only your doctor can make for your specific situation.
How much does Imipramine Hcl cost without insurance?
The price of Imipramine Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 72% off retail prices with a free Rx.com coupon.
What are the common side effects of Imipramine Hcl?
Common side effects of Imipramine Hcl may include: Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there, Fever, sore throat, cough, chills, Eye pain, vision changes, seeing halos around lights, Thoughts of hurting yourself or others, trouble sleeping, unusual behavior, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Imipramine Hcl?
Generic versions may be available for Imipramine Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Imipramine Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Imipramine Hcl?
The cheapest pharmacy for Imipramine Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Imipramine Hcl near you.

Imipramine Hcl Coupons & Prices

Imipramine HCl 25MG

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Imipramine Hcl Tablet — prescription drug image
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Imipramine Hcl 25mg (120)
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Looking for an imipramine HCl coupon? Imipramine hydrochloride is a widely available generic tricyclic antidepressant (sold under the brand name Tofranil), and because it is generic it is already one of the lower-cost options in its class. Even so, the cash price can vary a lot from one pharmacy to the next, so comparing pharmacies is the best way to pay less. Rx.com compares live prices at more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see today's price and get a free discount coupon you can use at the pharmacy counter.

What is imipramine and how does it work?

Imipramine hydrochloride is a tricyclic antidepressant (TCA), one of the older, well-established classes of medicines for mood. It is FDA-approved to relieve symptoms of depression, and endogenous depression tends to respond better than some other depressive states. It is also approved as short-term add-on therapy for nighttime bedwetting (nocturnal enuresis) in children age 6 and older. The brand name is Tofranil for imipramine HCl tablets; a related capsule form, Tofranil-PM, uses imipramine pamoate.

Like other TCAs, imipramine is thought to work by increasing the levels of certain natural chemical messengers in the brain that help regulate mood. It usually takes consistent daily use over several weeks to reach its full effect. This page is for general information only and is not medical advice, so talk with your doctor about whether imipramine is right for you.

Imipramine cost without insurance and how to save

Because imipramine is available as a generic, it is generally inexpensive compared with newer brand-name antidepressants. Still, the cash price you would pay without insurance is not the same everywhere. Different pharmacies set different prices for the exact same tablet, and the gap between the cheapest and most expensive pharmacy in your area can be surprisingly large. That is why it pays to compare before you fill.

There is no manufacturer savings card for generic imipramine. Instead, a free Rx.com discount coupon can be used at the pharmacy counter whether or not you have insurance, and often beats a standard cash price. Enter your ZIP above to see today's price at pharmacies near you and choose the lowest one.

Imipramine alternatives and related tricyclic antidepressants

Imipramine is one of several tricyclic antidepressants, and your doctor may consider a related medicine depending on your needs and how you tolerate side effects. Other TCAs include amitriptyline, nortriptyline (a metabolite of amitriptyline), desipramine (a metabolite of imipramine), doxepin, and clomipramine. All of these are available as generics.

Only your prescriber can decide which medicine fits your situation. If you have a prescription for any of them, you can compare live prices for each on Rx.com to see which pharmacy near you offers the best price today.

Important safety information

Imipramine carries a boxed warning: antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults, so anyone starting treatment should be watched closely for worsening mood or unusual changes, especially early on. Imipramine must not be taken with MAO inhibitors (risk of dangerous high blood pressure and serotonin syndrome) or during the early recovery period after a heart attack. It is cardiotoxic and dangerous in overdose because it has a narrow safety margin.

Common side effects include dry mouth, constipation, difficulty urinating, blurred vision, drowsiness, and dizziness when standing up (orthostatic hypotension). It can also lower the seizure threshold. Use extra caution if you have heart disease, glaucoma, or trouble urinating. This is a summary, not a complete list, and not medical advice. Review your full history and all your medicines with your doctor or pharmacist before starting or stopping imipramine.

Sources & accuracy

This Imipramine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Imipramine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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