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Nortriptyline Hcl

Nortriptyline HCl 10MG

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What is Nortriptyline Hcl?

If you are diagnosed with major depression, your doctor might prescribe nortriptyline. Since nortriptyline many cause unpleasant side effects (dry mouth, sedation, etc.) some doctors try other medications before using nortriptyline. Although not approved by the FDA, some doctors used nortriptyline to treat panic disorder, irritable bowel syndrome, and other disorders.

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What is Nortriptyline Hcl ?

If you are diagnosed with major depression, your doctor might prescribe nortriptyline. Since nortriptyline many cause unpleasant side effects (dry mouth, sedation, etc.) some doctors try other medications before using nortriptyline. Although not approved by the FDA, some doctors used nortriptyline to treat panic disorder, irritable bowel syndrome, and other disorders.
  • Seizures or tremors
  • Sudden or severe headache, problems with speech or walking
  • Thoughts of hurting yourself or others, unusual behavior
  • Unexplained fainting
  • Fast, pounding, or uneven heartbeat
  • Change in how much or how often you urinate, problems urinating
  • Anxiety, restlessness, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Eye pain, vision changes, seeing halos around lights
  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, dizziness, lightheadedness
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • This medicine may cause the following problems:Increased risk of heart attack, hearth rhythm problems, or strokeSerotonin syndrome (especially when used with certain medicines)Eye or vision problems
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease (including Brugada syndrome), heart rhythm problems, glaucoma, depression, thyroid problems, trouble urinating, or a history of seizures or other mental problems.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
What is nortriptyline used for?
Nortriptyline is FDA-approved to treat depression (major depressive disorder). It is a tricyclic antidepressant that works by increasing norepinephrine and serotonin in the brain. Your prescriber can tell you whether it is appropriate for your situation.
Is nortriptyline a good antidepressant?
Nortriptyline is an established, effective antidepressant that has been used for decades. As a secondary-amine tricyclic, it often causes fewer sedating and anticholinergic side effects than some older TCAs. Whether it is a good choice for you depends on your health history and other medications, which is a conversation to have with your prescriber.
What are the most common side effects of nortriptyline?
The most common side effects are anticholinergic: dry mouth, constipation, blurred vision, urinary retention, drowsiness, weight gain, and dizziness when standing up (orthostatic hypotension). Contact your doctor if side effects are bothersome or persistent.
How long does it take for nortriptyline to work?
For depression, tricyclic antidepressants like nortriptyline generally take several weeks of regular use before the full benefit is felt, though some effects may appear sooner. Take it exactly as prescribed and do not stop on your own. Ask your prescriber what to expect for your treatment.
Is nortriptyline the same as amitriptyline?
They are closely related but not the same. Nortriptyline is a secondary-amine tricyclic antidepressant and is actually one of the substances the body produces when it breaks down amitriptyline. Nortriptyline tends to cause fewer sedating side effects for many people. Only your prescriber can decide which is right for you.
How much does Nortriptyline Hcl cost without insurance?
The price of Nortriptyline Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 61% off retail prices with a free Rx.com coupon.
What are the common side effects of Nortriptyline Hcl?
Common side effects of Nortriptyline Hcl may include: Seizures or tremors, Sudden or severe headache, problems with speech or walking, Thoughts of hurting yourself or others, unusual behavior, Unexplained fainting, Fast, pounding, or uneven heartbeat. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Nortriptyline Hcl?
Generic versions may be available for Nortriptyline Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Nortriptyline Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Nortriptyline Hcl?
The cheapest pharmacy for Nortriptyline Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Nortriptyline Hcl near you.

Nortriptyline Hcl Coupons & Prices

Nortriptyline HCl 10MG

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Nortriptyline Hcl Capsule — prescription drug image
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Nortriptyline Hcl 25mg (90)
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Nortriptyline Hcl prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
10mg · Capsule 30 $14.99 $4.00
25mg · Capsule 30 $35.10 $4.00
50mg · Capsule 30 $19.99 $4.00
75mg · Capsule 30 $23.79 $16.19

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a nortriptyline HCl coupon? Nortriptyline hydrochloride is an inexpensive generic tricyclic antidepressant (the brands Pamelor and Aventyl are discontinued in the U.S.), but the cash price can still vary widely from one pharmacy to the next. Rx.com compares live, discounted prices across more than 60,000 pharmacies so you can find the lowest cost near you. No insurance needed and no sign-up required. Enter your ZIP above to see today's price and print or show a free discount coupon at the counter.

What is nortriptyline and how does it work?

Nortriptyline hydrochloride is a secondary-amine tricyclic antidepressant (TCA). It is FDA-approved to treat depression (major depressive disorder) and works by increasing the levels of two natural brain chemicals, norepinephrine and serotonin, which help regulate mood. Nortriptyline is one of the older, well-established antidepressants and is available only by prescription.

Beyond depression, doctors have long prescribed nortriptyline for other conditions based on their clinical judgment. Whether it is right for you is a decision for your prescriber, who will weigh your full health history. This page is for price information only and is not medical advice.

Nortriptyline cost without insurance and how to save

Nortriptyline is a generic medication, so it is already one of the more affordable options in its class, but the cash price is not the same everywhere. The same prescription can cost noticeably more at one pharmacy than at another across town, which is exactly why comparing pharmacies matters. There is no manufacturer savings card for nortriptyline because the brands are discontinued, so a free pharmacy discount coupon is usually the best way to lower the cash price if you are paying without insurance.

Rx.com pulls live, discounted prices from more than 60,000 pharmacies and shows them side by side. Enter your ZIP above to see today's price near you, then print or show the coupon at checkout. It is free to use and there is no membership.

Nortriptyline vs. amitriptyline and other alternatives

Nortriptyline is closely related to amitriptyline - in fact, the body converts some amitriptyline into nortriptyline. Nortriptyline is a secondary-amine TCA and tends to cause fewer sedating and anticholinergic side effects than amitriptyline for many people. Other tricyclic antidepressants in the same family include desipramine and imipramine.

If your prescriber is treating you for a different condition, they may consider newer options such as duloxetine or gabapentin. Only your provider can decide which medication fits your needs. All of these generics are available on Rx.com, so you can compare the cash price of each by entering your ZIP above.

Important safety information

Nortriptyline carries a boxed warning for an increased risk of suicidal thoughts and behavior in children, adolescents, and young adults up to age 24; it is not approved for use in children. It must not be taken with, or within 14 days of, an MAO inhibitor, and the antibiotic linezolid and intravenous methylene blue are also off-limits because of the risk of serotonin syndrome. It should not be started during the acute recovery period after a heart attack. Because TCAs can be dangerous and even fatal in overdose, keep it stored safely.

Common side effects are largely anticholinergic and include dry mouth, constipation, blurred vision, urinary retention, drowsiness, weight gain, and dizziness on standing. Use extra caution if you have heart disease, an irregular heartbeat, glaucoma, or a seizure disorder. Do not stop suddenly - your prescriber will usually taper the dose to avoid withdrawal. This is general information, not medical advice; talk with your doctor or pharmacist about your specific situation.

Sources & accuracy

This Nortriptyline Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Nortriptyline Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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