Trulance
Trulance 30 Tablets
What is Trulance?
Trulance is a medication used to help adults with chronic constipation and irritable bowel syndrome that causes constipation. It works by helping food and waste move through the stomach and intestines more easily.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Severe diarrhea
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have other stomach or bowel problems.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Prescription savings · · · ·
What is Trulance ?
Trulance is a medication used to help adults with chronic constipation and irritable bowel syndrome that causes constipation. It works by helping food and waste move through the stomach and intestines more easily.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Severe diarrhea
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have other stomach or bowel problems.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Trulance Coupons & Prices
Trulance 30 Tablets
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a Trulance coupon? Trulance (plecanatide) is a once-daily prescription tablet from Salix used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It is a brand-name medicine with no generic, so the cash price often runs $550 or more for a one-month supply without insurance, though it varies by pharmacy. A free Rx.com Trulance coupon lets you compare cash prices at more than 60,000 U.S. pharmacies and show the coupon at the counter — no membership, no signup, and nothing to pay Rx.com. Enter your ZIP code above to see today's lowest Trulance price near you.
What is Trulance (plecanatide) and how does it work?
Trulance is the brand name for plecanatide, a prescription medicine that belongs to a class called guanylate cyclase-C (GC-C) agonists. It works in the lining of the intestine to increase fluid and help stool move through the bowel more easily, which can relieve the hard, infrequent stools of chronic constipation.
Doctors prescribe Trulance for adults with chronic idiopathic constipation (CIC) and for adults with irritable bowel syndrome with constipation (IBS-C). It is taken as a single 3 mg tablet once a day, with or without food.
How much does Trulance cost without insurance?
Trulance is a brand-name drug with no generic version available, which is the main reason the cash price is high. Prices also vary by pharmacy and location — the same prescription can differ by a wide margin between two pharmacies in the same town. That price gap is exactly why comparing pharmacies with a coupon matters. Enter your ZIP code above to see live cash prices near you and pull up a free coupon for the lowest one.
Trulance coupon vs. the manufacturer savings card
Salix offers a Trulance manufacturer savings program, but copay cards like this are generally limited to patients with commercial (private) insurance and typically exclude people with Medicare, Medicaid, or no insurance. If you are paying cash or your plan does not cover Trulance, a free Rx.com discount coupon is often the more useful option because anyone can use it regardless of insurance status. Check the manufacturer eligibility terms and compare them against the Rx.com cash price above to see which is lower for you.
Trulance vs. Linzess and Amitiza
Trulance is one of a few prescription options for chronic constipation and IBS-C. Linzess (linaclotide) is another once-daily GC-C agonist that works in a similar way, while Amitiza (lubiprostone) works through a different mechanism. Each has different dosing, side effects, and cost, so the right choice is a decision for you and your doctor. If you are prescribed a different constipation medicine, you can pull up a free Rx.com coupon for it the same way you would for Trulance.
Important Trulance safety information
Trulance carries a boxed warning: it must not be given to children under 2 years old, and it should be avoided in children 2 to under 6, because of the risk of serious dehydration. The most common side effect in adults is diarrhea, which can sometimes be severe — stop taking Trulance and call your doctor if you get severe diarrhea. This information is educational and is not a substitute for medical advice; always follow your doctor and pharmacist's instructions.
This Trulance information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Trulance on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.